You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/75522
Full metadata record
DC FieldValueLanguage
dc.contributor.authorde Matos, Renata Prandini Adum-
dc.contributor.authorSichero, Laura-
dc.contributor.authorMansur, Isabela Mazuco-
dc.contributor.authordo Bonfim, Caroline Measso-
dc.contributor.authorBittar, Cíntia-
dc.contributor.authorNogueira, Rodrigo Lacerda-
dc.contributor.authorKüpper, Daniel Salgado-
dc.contributor.authorValera, Fabiana Cardoso Pereira-
dc.contributor.authorNogueira, Maurício Lacerda-
dc.contributor.authorVilla, Luisa Lina-
dc.contributor.authorCalmon, Marilia Freitas-
dc.contributor.authorRahal, Paula-
dc.date.accessioned2014-05-27T11:29:35Z-
dc.date.accessioned2016-10-25T18:48:57Z-
dc.date.available2014-05-27T11:29:35Z-
dc.date.available2016-10-25T18:48:57Z-
dc.date.issued2013-06-01-
dc.identifierhttp://dx.doi.org/10.1016/j.meegid.2012.12.033-
dc.identifier.citationInfection, Genetics and Evolution, v. 16, p. 282-289.-
dc.identifier.issn1567-1348-
dc.identifier.issn1567-7257-
dc.identifier.urihttp://hdl.handle.net/11449/75522-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75522-
dc.description.abstractThere are few studies about the distribution of natural molecular variants of low-risk HPVs. Our aim was to evaluate the E6 early gene variability among HPV-6 and HPV-11 isolates detected in recurrent respiratory papillomatosis (RRP) samples obtained in a cohort of Brazilian patients. We also performed a phylogenetic analysis in order to compare nucleotide sequences identified in our study with previously reported isolates from different anatomic sites (laryngeal papillomas, genital warts, cervical cancer and anal swabs) obtained from other parts of the world to determine the phylogenetic relationships of variants detected in Brazil. The complete coding region of the E6 gene of 25 samples was cloned and sequenced: 18 isolates of HPV-6 (72%) and 7 isolates of HPV-11 (28%). A total of four different HPV-6 genomic variants and two HPV-11 genomic variants was identified. It was not possible to correlate specific variants with disease severity. Phylogenetic trees for both HPV types were constructed enclosing both E6 sequences detected in our study and formerly published sequences. In both phylogenetic trees, the sequences from Brazil did not group together. We could not establish a geographical association between HPV-6 or HPV-11 variants, unlike HPV-16 and HPV-18. © 2013 Elsevier B.V.en
dc.format.extent282-289-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectHPV variants-
dc.subjectHPV-11-
dc.subjectHPV-6-
dc.subjectPhylogenetic analysis-
dc.subjectRecurrent respiratory papillomatosis-
dc.subjectprotein E6-
dc.subjectadolescent-
dc.subjectadult-
dc.subjectamino acid substitution-
dc.subjectBrazil-
dc.subjectchild-
dc.subjectclinical article-
dc.subjectcohort analysis-
dc.subjectcondyloma acuminatum-
dc.subjectcontrolled study-
dc.subjectdisease severity-
dc.subjectE6 early gene-
dc.subjectfemale-
dc.subjectgenetic variability-
dc.subjecthuman-
dc.subjectHuman papillomavirus type 11-
dc.subjectHuman papillomavirus type 6-
dc.subjectlarynx papillomatosis-
dc.subjectlung tumor-
dc.subjectmale-
dc.subjectmolecular cloning-
dc.subjectnonhuman-
dc.subjectnucleic acid analysis-
dc.subjectnucleotide sequence-
dc.subjectpapillomatosis-
dc.subjectphylogenetic tree-
dc.subjectphylogeny-
dc.subjectpoint mutation-
dc.subjectpolymerase chain reaction-
dc.subjectpreschool child-
dc.subjectpriority journal-
dc.subjectschool child-
dc.subjectsequence analysis-
dc.subjecttumor recurrence-
dc.subjectuterine cervix cancer-
dc.subjectvirus isolation-
dc.titleNucleotide and phylogenetic analysis of human papillomavirus types 6 and 11 isolated from recurrent respiratory papillomatosis in Brazilen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionLaboratory of Research in Virology-
dc.contributor.institutionThe Cancer Institute of the State of Sao Paulo-
dc.contributor.institutionSanta Casa College of Medical Sciences, São Paulo-
dc.description.affiliationUNESP - São Paulo State University, IBILCE Institute of Bioscience, Language and Literature and Exact Science Department of Biology, Rua Cristovao Colombo 2265, Bairro Jardim Nazareth, CEP 15054-010, Sao José do Rio Preto, Sao Paulo-
dc.description.affiliationUSP - University of Sao Paulo School of Medicine of Ribeirão Preto Department of Ophthalmology, Otorhinolaryngology and Surgery Head/Neck, Av. Bandeirantes, 3900 Bairro Monte Alegre, CEP 14049-900, Ribeirão Preto, SP-
dc.description.affiliationFAMERP School of Medicine of Sao Jose do Rio Preto Laboratory of Research in Virology, Av. Brigadeiro Faria Lima, 5416 Bairro Vila Sao Pedro, CEP 15090-000, São José do Rio Preto, SP-
dc.description.affiliationICESP Center for Translational Research in Oncology The Cancer Institute of the State of Sao Paulo, Av. Dr. Arnaldo, 251, 8 andar, Bairro Cerqueira Cesar, CEP 01246-000, São Paulo-
dc.description.affiliationDepartament of Radiology and Oncology School of Medicine University of São Paulo, USP, Av. Dr. Eneas de Carvalho Aguiar, s/n - Rua 1, Cerqueira Cesar, SP, CEP 05403-900, São Paulo-
dc.description.affiliationHPV Institute Santa Casa College of Medical Sciences, São Paulo, Rua Marquês de Itú, 381, Santa Cecília, CEP 01223-001, São Paulo-
dc.description.affiliationUnespUNESP - São Paulo State University, IBILCE Institute of Bioscience, Language and Literature and Exact Science Department of Biology, Rua Cristovao Colombo 2265, Bairro Jardim Nazareth, CEP 15054-010, Sao José do Rio Preto, Sao Paulo-
dc.identifier.doi10.1016/j.meegid.2012.12.033-
dc.identifier.wosWOS:000320569500037-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84877817788.pdf-
dc.relation.ispartofInfection, Genetics and Evolution-
dc.identifier.scopus2-s2.0-84877817788-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.