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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/75638
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dc.contributor.authorAlves, Markênia Kélia Santos-
dc.contributor.authorFaria, Mário Henrique Girão-
dc.contributor.authorNeves Filho, Eduardo Henrique Cunha-
dc.contributor.authorFerrasi, Adriana Camargo-
dc.contributor.authorPardini, Maria Ines de Moura Campos-
dc.contributor.authorMoraes Filho, Manoel Odorico de-
dc.contributor.authorRabenhorst, Silvia Helena Barem-
dc.date.accessioned2014-05-27T11:29:40Z-
dc.date.accessioned2016-10-25T18:49:44Z-
dc.date.available2014-05-27T11:29:40Z-
dc.date.available2016-10-25T18:49:44Z-
dc.date.issued2013-06-12-
dc.identifierhttp://dx.doi.org/10.1016/j.ijsu.2013.05.030-
dc.identifier.citationInternational Journal of Surgery, v. 11, n. 7, p. 549-553, 2013.-
dc.identifier.issn1743-9191-
dc.identifier.issn1743-9159-
dc.identifier.urihttp://hdl.handle.net/11449/75638-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75638-
dc.description.abstractCDKN2A promoter hypermethylation has been widely related to many cancers. In astrocytomas, although CDKN2A (p16INK4A protein) is often inactivated, there are still some controversial issues regarding the mechanism by which this alteration occurs. Thus, we analyzed a series of astrocytomas to assess the association between CDKN2A expression and methylation of grade I-IV tumors (WHO) and clinicopathological parameters. DNA extracted from formalin-fixed paraffin-embedded material of 93 astrocytic tumors was available for CDKN2A promoter methylation analysis and p16INK4A expression by methylation-specific PCR and immunohistochemistry, respectively. A strong negative correlation between nuclear and cytoplasmic immunostaining and CDKN2A promoter methylation was found. Additionally, a significant negative correlation between CDKN2A promoter methylation and age was observed; also, female patients had statistically more CDKN2A methylated promoters (p=0.036) than men. In conclusion, CDKN2A inactivation by promoter methylation is a frequent event in astrocytomas and it is related to the age and sex of patients. © 2013 Surgical Associates Ltd.en
dc.format.extent549-553-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAge-
dc.subjectAstrocytic tumors-
dc.subjectCDKN2A Methylation-
dc.subjectExpression-
dc.subjectP16-
dc.subjectcyclin dependent kinase inhibitor 2A-
dc.subjectDNA-
dc.subjectadolescent-
dc.subjectadult-
dc.subjectage-
dc.subjectaged-
dc.subjectastrocytoma-
dc.subjectchild-
dc.subjectDNA extraction-
dc.subjectfemale-
dc.subjectgene expression-
dc.subjecthuman-
dc.subjecthuman tissue-
dc.subjectimmunohistochemistry-
dc.subjectmajor clinical study-
dc.subjectmale-
dc.subjectpreschool child-
dc.subjectpriority journal-
dc.subjectpromoter region-
dc.subjectprotein methylation-
dc.subjectschool child-
dc.subjectsex difference-
dc.titleCDKN2A promoter hypermethylation in astrocytomas is associated with age and sexen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal do Ceará (UFC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Federal do Ceará Department of Pathology and Forensic Medicine, Rua Alexandre Baraúna, 949, Porangabussu, CEP 60183-630 Fortaleza-
dc.description.affiliationUniversidade Estadual Paulista - UNESP Botucatu Medical School Molecular Biology Laboratory of Blood Transfusion Center, Distrito de Rubião Junior, s/n, CEP 18.618-000 Botucatu-
dc.description.affiliationUniversidade Federal do Ceará Department of Physiology and Pharmacology, Rua Coronel Nunes de Melo, 1127, Porangabussu, CEP 60430-270 Fortaleza-
dc.description.affiliationUnespUniversidade Estadual Paulista - UNESP Botucatu Medical School Molecular Biology Laboratory of Blood Transfusion Center, Distrito de Rubião Junior, s/n, CEP 18.618-000 Botucatu-
dc.identifier.doi10.1016/j.ijsu.2013.05.030-
dc.identifier.wosWOS:000321750800011-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInternational Journal of Surgery-
dc.identifier.scopus2-s2.0-84880329284-
dc.identifier.scopus2-s2.0-84878686126-
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