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dc.contributor.authorTrapé, Atila Alexandre-
dc.contributor.authorJacomini, AndréMourão-
dc.contributor.authorMuniz, Jaqueline Jóice-
dc.contributor.authorSertorio, Jonas Tadeu Cau-
dc.contributor.authorTanus-Santos, José Eduardo-
dc.contributor.authorAmaral, Sandra Lia do-
dc.contributor.authorZago, Anderson Saranz-
dc.identifier.citationBMC Cardiovascular Disorders, v. 13.-
dc.description.abstractBackground: Hypertension can be generated by a great number of mechanisms including elevated uric acid (UA) that contribute to the anion superoxide production. However, physical exercise is recommended to prevent and/or control high blood pressure (BP). The purpose of this study was to investigate the relationship between BP and UA and whether this relationship may be mediated by the functional fitness index.Methods: All participants (n = 123) performed the following tests: indirect maximal oxygen uptake (VO2max), AAHPERD Functional Fitness Battery Test to determine the general fitness functional index (GFFI), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and blood sample collection to evaluate the total-cholesterol (CHOL), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), triglycerides (TG), uric acid (UA), nitrite (NO2) and thiobarbituric acid reactive substances (T-BARS). After the physical, hemodynamic and metabolic evaluations, all participants were allocated into three groups according to their GFFI: G1 (regular), G2 (good) and G3 (very good).Results: Baseline blood pressure was higher in G1 when compared to G3 (+12% and +11%, for SBP and DBP, respectively, p<0.05) and the subjects who had higher values of BP also presented higher values of UA. Although UA was not different among GFFI groups, it presented a significant correlation with GFFI and VO2max. Also, nitrite concentration was elevated in G3 compared to G1 (140±29 μM vs 111± 29 μM, for G3 and G1, respectively, p<0.0001). As far as the lipid profile, participants in G3 presented better values of CHOL and TG when compared to those in G1.Conclusions: Taking together the findings that subjects with higher BP had elevated values of UA and lower values of nitrite, it can be suggested that the relationship between blood pressure and the oxidative stress produced by acid uric may be mediated by training status. © 2013 Trapé et al.; licensee BioMed Central Ltd.en
dc.subjectBlood pressure-
dc.subjectNitric oxide-
dc.subjectOxidative stress-
dc.subjectTraining status-
dc.subjectUric acid-
dc.subjecthigh density lipoprotein cholesterol-
dc.subjectlow density lipoprotein cholesterol-
dc.subjectthiobarbituric acid reactive substance-
dc.subjecturic acid-
dc.subjectblood sampling-
dc.subjectbody mass-
dc.subjectcholesterol blood level-
dc.subjectclinical evaluation-
dc.subjectcorrelation analysis-
dc.subjectdiastolic blood pressure-
dc.subjectmajor clinical study-
dc.subjectoxidative stress-
dc.subjectoxygen consumption-
dc.subjectpriority journal-
dc.subjectsystolic blood pressure-
dc.subjecttriacylglycerol blood level-
dc.subjecturic acid blood level-
dc.titleThe relationship between training status, blood pressure and uric acid in adults and elderlyen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationFaculty of Medicine University of São Paulo, Ribeirão Preto, SP-
dc.description.affiliationDepartment of Physical Education Unesp São Paulo State University, Bauru, SP-
dc.description.affiliationUnespDepartment of Physical Education Unesp São Paulo State University, Bauru, SP-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBMC Cardiovascular Disorders-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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