Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/75767
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Badial, Peres R. | - |
dc.contributor.author | Rashmir-Raven, Ann M. | - |
dc.contributor.author | Cagnini, Didier Q. | - |
dc.contributor.author | Oliveira-Filho, José P. | - |
dc.contributor.author | Cooley, Avery J. | - |
dc.contributor.author | Cunha, Paulo Henrique J. | - |
dc.contributor.author | Kitchell, Barbara E. | - |
dc.contributor.author | Conceição, Lissandro G. | - |
dc.contributor.author | Mochal, Cathleen A. | - |
dc.contributor.author | Borges, Alexandre Secorun | - |
dc.date.accessioned | 2014-05-27T11:29:49Z | - |
dc.date.accessioned | 2016-10-25T18:50:19Z | - |
dc.date.available | 2014-05-27T11:29:49Z | - |
dc.date.available | 2016-10-25T18:50:19Z | - |
dc.date.issued | 2013-07-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.jevs.2012.03.004 | - |
dc.identifier.citation | Journal of Equine Veterinary Science, v. 33, n. 7, p. 515-522, 2013. | - |
dc.identifier.issn | 0737-0806 | - |
dc.identifier.uri | http://hdl.handle.net/11449/75767 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/75767 | - |
dc.description.abstract | Two Quarter Horse mares with hereditary equine regional dermal asthenia (HERDA) were diagnosed with metastatic squamous cell carcinoma (SCC) associated with chronic nonhealing wounds. The lesions were similar to the development of SCC from chronic nonhealing ulcers, known as Marjolin's ulcers in humans. The horses showed recurrent skin wounds in the saddle and paralumbar regions and were confirmed by molecular techniques as having HERDA. Both horses were maintained as research animals for prolonged periods and received regular veterinary care and wound treatment. Both horses were ultimately euthanized because of their chronic progressive wounds, coupled with declining health. At necropsy, the nonhealing wounds were found to be complicated by infiltrative SCC; both horses had metastasis to lungs. Chronically inflamed, recurrent skin wounds that heal slowly and incompletely as a consequence of HERDA are proposed as a major pathogenetic factor in tumorigenesis. Consistent findings with respect to proliferation index (Ki-67) and mutations of p53 tumor suppressor gene were confirmed by immunohistochemistry in one horse. SCC consistent with Marjolin's ulcer has been previously suggested in association with chronic ulcers or burn scars in horses, but this is the first report of an association with chronic poor healing wounds in HERDA horses. © 2013 Elsevier Inc. | en |
dc.format.extent | 515-522 | - |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | HERDA | - |
dc.subject | Horse | - |
dc.subject | Marjolin's ulcer | - |
dc.subject | Squamous cell carcinoma | - |
dc.subject | Animalia | - |
dc.subject | Equidae | - |
dc.title | Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Michigan State University | - |
dc.contributor.institution | Mississippi State University | - |
dc.contributor.institution | Universidade Federal de Goiás (UFG) | - |
dc.contributor.institution | Universidade Federal de Viçosa (UFV) | - |
dc.description.affiliation | Department of Veterinary Clinical Science School of Veterinary Medicine and Animal Science Universidade Estadual Paulista (UNESP), Botucatu, São Paulo | - |
dc.description.affiliation | Department of Large Animal Clinical Sciences College of Veterinary Medicine Michigan State University, East Lansing, MI | - |
dc.description.affiliation | Department of Pathobiology and Population Medicine Mississippi State University, Mississippi State, MS | - |
dc.description.affiliation | Department of Veterinary Medicine School of Veterinary Medicine Universidade Federal de Goiás (UFG), Goiânia, Goiás | - |
dc.description.affiliation | Department of Small Animal Clinical Sciences College of Veterinary Medicine Michigan State University, East Lansing, MI | - |
dc.description.affiliation | Department of Veterinary Medicine Universidade Federal de Viçosa (UFV), Viçosa, Minas Gerais | - |
dc.description.affiliation | Department of Clinical Sciences Mississippi State University, Mississippi, MS | - |
dc.description.affiliationUnesp | Department of Veterinary Clinical Science School of Veterinary Medicine and Animal Science Universidade Estadual Paulista (UNESP), Botucatu, São Paulo | - |
dc.identifier.doi | 10.1016/j.jevs.2012.03.004 | - |
dc.identifier.wos | WOS:000321794000006 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | 2-s2.0-84879779708.pdf | - |
dc.relation.ispartof | Journal of Equine Veterinary Science | - |
dc.identifier.scopus | 2-s2.0-84879779708 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.