You are in the accessibility menu

Please use this identifier to cite or link to this item:
SFlt-1/PlGF ratio as a prognostic marker of adverse outcomes in women with early-onset preeclampsia
  • Universidade Federal de São Paulo (UNIFESP)
  • Hospital e Maternidade Vila Nova Cachoeirinha
  • Universidade Estadual Paulista (UNESP)
  • Laboratory of Clinical Pathology Salomão and Zoppi
Soluble fms-like tyrosine kinase 1 (sFlt-1) is an anti-angiogenic factor released in higher amounts by preeclamptic placentas and it has been implicated in the endothelial dysfunction observed in the disease. In this study we evaluated if circulating sFlt-1/PlGF ratio is useful to predict adverse outcomes in women with early-onset preeclampsia. This is a cohort study of 88 preeclamptic women with singleton pregnancies at ≤35 weeks of gestation. According to definitions used, adverse outcomes occurred in 46.5% (N = 43) of the patients. The median sFlt1/PlGF ratio (25th-75th centile) for all patients evaluated was of 42.26 (13.1-226.1). The median sFlt-1/PlGF ratio among women who had any adverse outcome (N = 43) versus no adverse outcomes (N = 45) was of 227.6 (80.3-346.1) versus 14.4 (3.35-30.0), (P < 0.0001). According to our analyses a sFlt-1/PlGF ratio cut-point of ≥85 gave a sensitivity of 74.0% and specificity of 97.0%. The positive predictive value and the negative predictive value were 96.0% and 80.0%, respectively. The median sFlt-1/PlGF ratio (25th-75th centile) for patients who delivered within <7 days was 260.0 (127.7-404.7) as compared to 14.4 (3.35-34.97) for those patients who delivered within two weeks or more (P < 0.0001). Our results suggest that sFlt-1/PlGF ratio is a promising marker for adverse outcomes in women with early-onset preeclampsia. © 2013 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
Issue Date: 
Pregnancy Hypertension, v. 3, n. 3, p. 191-195, 2013.
Time Duration: 
  • Inflammation
  • PlGF
  • Preeclampsia
  • sFlt-1
  • placental growth factor
  • vasculotropin receptor 1
  • adult
  • Brazil
  • cohort analysis
  • controlled study
  • diagnostic test accuracy study
  • disease marker
  • female
  • gestational age
  • human
  • major clinical study
  • predictive value
  • preeclampsia
  • pregnancy outcome
  • priority journal
  • prognosis
  • protein blood level
  • receiver operating characteristic
  • sensitivity and specificity
Access Rights: 
Acesso restrito
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.