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http://acervodigital.unesp.br/handle/11449/75775
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DC Field | Value | Language |
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dc.contributor.author | Oliveira, Leandro Gustavo de | - |
dc.contributor.author | Peraçoli, José Carlos | - |
dc.contributor.author | Peraçoli, Maria Terezinha Serrão | - |
dc.contributor.author | Korkes, Henri | - |
dc.contributor.author | Zampieri, Giafranco | - |
dc.contributor.author | Moron, Antonio F. | - |
dc.contributor.author | Sass, Nelson | - |
dc.date.accessioned | 2014-05-27T11:29:49Z | - |
dc.date.accessioned | 2016-10-25T18:50:20Z | - |
dc.date.available | 2014-05-27T11:29:49Z | - |
dc.date.available | 2016-10-25T18:50:20Z | - |
dc.date.issued | 2013-07-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.preghy.2013.02.003 | - |
dc.identifier.citation | Pregnancy Hypertension, v. 3, n. 3, p. 191-195, 2013. | - |
dc.identifier.issn | 2210-7789 | - |
dc.identifier.uri | http://hdl.handle.net/11449/75775 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/75775 | - |
dc.description.abstract | Soluble fms-like tyrosine kinase 1 (sFlt-1) is an anti-angiogenic factor released in higher amounts by preeclamptic placentas and it has been implicated in the endothelial dysfunction observed in the disease. In this study we evaluated if circulating sFlt-1/PlGF ratio is useful to predict adverse outcomes in women with early-onset preeclampsia. This is a cohort study of 88 preeclamptic women with singleton pregnancies at ≤35 weeks of gestation. According to definitions used, adverse outcomes occurred in 46.5% (N = 43) of the patients. The median sFlt1/PlGF ratio (25th-75th centile) for all patients evaluated was of 42.26 (13.1-226.1). The median sFlt-1/PlGF ratio among women who had any adverse outcome (N = 43) versus no adverse outcomes (N = 45) was of 227.6 (80.3-346.1) versus 14.4 (3.35-30.0), (P < 0.0001). According to our analyses a sFlt-1/PlGF ratio cut-point of ≥85 gave a sensitivity of 74.0% and specificity of 97.0%. The positive predictive value and the negative predictive value were 96.0% and 80.0%, respectively. The median sFlt-1/PlGF ratio (25th-75th centile) for patients who delivered within <7 days was 260.0 (127.7-404.7) as compared to 14.4 (3.35-34.97) for those patients who delivered within two weeks or more (P < 0.0001). Our results suggest that sFlt-1/PlGF ratio is a promising marker for adverse outcomes in women with early-onset preeclampsia. © 2013 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. | en |
dc.format.extent | 191-195 | - |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | Inflammation | - |
dc.subject | PlGF | - |
dc.subject | Preeclampsia | - |
dc.subject | sFlt-1 | - |
dc.subject | placental growth factor | - |
dc.subject | vasculotropin receptor 1 | - |
dc.subject | adult | - |
dc.subject | Brazil | - |
dc.subject | cohort analysis | - |
dc.subject | controlled study | - |
dc.subject | diagnostic test accuracy study | - |
dc.subject | disease marker | - |
dc.subject | female | - |
dc.subject | gestational age | - |
dc.subject | human | - |
dc.subject | major clinical study | - |
dc.subject | predictive value | - |
dc.subject | preeclampsia | - |
dc.subject | pregnancy outcome | - |
dc.subject | priority journal | - |
dc.subject | prognosis | - |
dc.subject | protein blood level | - |
dc.subject | receiver operating characteristic | - |
dc.subject | sensitivity and specificity | - |
dc.title | SFlt-1/PlGF ratio as a prognostic marker of adverse outcomes in women with early-onset preeclampsia | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | - |
dc.contributor.institution | Hospital e Maternidade Vila Nova Cachoeirinha | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Laboratory of Clinical Pathology Salomão and Zoppi | - |
dc.description.affiliation | Obstetrics Department Universidade Federal de São Paulo, 875 Vila Clementino, São Paulo 04024 | - |
dc.description.affiliation | Laboratory of Clinical and Experimental Investigation Hospital e Maternidade Vila Nova Cachoeirinha, São Paulo | - |
dc.description.affiliation | Obstetrics Department Universidade Estadual Paulista, Botucatu | - |
dc.description.affiliation | Laboratory of Clinical Pathology Salomão and Zoppi, São Paulo | - |
dc.description.affiliationUnesp | Obstetrics Department Universidade Estadual Paulista, Botucatu | - |
dc.identifier.doi | 10.1016/j.preghy.2013.02.003 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Pregnancy Hypertension | - |
dc.identifier.scopus | 2-s2.0-84878870151 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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