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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7577
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dc.contributor.authorSilva, M.-
dc.contributor.authorLara, A. S.-
dc.contributor.authorLeite, CQF-
dc.contributor.authorFerreira, E. I.-
dc.date.accessioned2014-05-20T13:24:26Z-
dc.date.accessioned2016-10-25T16:45:09Z-
dc.date.available2014-05-20T13:24:26Z-
dc.date.available2016-10-25T16:45:09Z-
dc.date.issued2001-06-01-
dc.identifierhttp://dx.doi.org/10.1002/1521-4184(200106)334:6<189-
dc.identifier.citationArchiv Der Pharmazie. Berlin: Wiley-v C H Verlag Gmbh, v. 334, n. 6, p. 189-193, 2001.-
dc.identifier.issn0365-6233-
dc.identifier.urihttp://hdl.handle.net/11449/7577-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7577-
dc.description.abstractWith the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium Il(tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.en
dc.format.extent189-193-
dc.language.isodeu-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectpotential tuberculostatic agentpt
dc.subjectisoniazidpt
dc.subjectprodrugpt
dc.subjectmicelle-forming polymerpt
dc.subjectco-polymer poly(ethylene glycol)-poly(aspartic acid)pt
dc.titlePotential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniaziden
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, BR-05508970 São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.doi10.1002/1521-4184(200106)334:6<189-
dc.identifier.wosWOS:000169717500002-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArchiv Der Pharmazie-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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