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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/75780
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dc.contributor.authorFerreira, Ana Silvia Sartori Barraviera Seabra-
dc.contributor.authorBarraviera, Benedito-
dc.contributor.authorBarraviera, Silvia Regina Catharino Sartori-
dc.contributor.authorAbbade, Luciana Patrícia Fernandes-
dc.contributor.authorCaramori, Carlos Antonio-
dc.contributor.authorFerreira, Rui Seabra-
dc.date.accessioned2014-05-27T11:29:49Z-
dc.date.accessioned2016-10-25T18:50:21Z-
dc.date.available2014-05-27T11:29:49Z-
dc.date.available2016-10-25T18:50:21Z-
dc.date.issued2013-07-01-
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2013.01.003-
dc.identifier.citationToxicon, v. 69, p. 50-54.-
dc.identifier.issn0041-0101-
dc.identifier.issn1879-3150-
dc.identifier.urihttp://hdl.handle.net/11449/75780-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75780-
dc.description.abstractBasic research is fundamental for discovering potential diagnostic and therapeutic tools, including drugs, vaccines and new diagnostic techniques. On this basis, diagnosis and treatment methods for many diseases have been developed. Presently, discovering new candidate molecules and testing them in animals are relatively easy tasks that require modest resources and responsibility. However, crossing the animal-to-human barrier is still a great challenge that most researchers tend to avoid. Thus, bridging this current gap between clinical and basic research must be encouraged and elucidated in training programmes for health professionals. This project clearly shows the challenges faced by a group of Brazilian researchers who, after discovering a new fibrin sealant through 20 years of painstaking basic work, insisted on having the product applied clinically. The Brazilian government has recently become aware of this challenge and has accordingly defined the product as strategic to the public health of the country. Thus, in addition to financing research and development laboratories, resources were invested in clinical trials and in the development of a virtual platform termed the Virtual System to Support Clinical Research (SAVPC); this platform imparts speed, reliability and visibility to advances in product development, fostering interactions among sponsors, physicians, students and, ultimately, the research subjects themselves. This pioneering project may become a future model for other public institutions in Brazil, principally in overcoming neglected diseases, which unfortunately continue to afflict this tropical country. © 2013 Elsevier Ltd.en
dc.format.extent50-54-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectFibrin sealanten
dc.subjectGAPen
dc.subjectTranslational potentialen
dc.subjectTranslational researchen
dc.subjectfibrin glueen
dc.subjectvaccineen
dc.subjectbasic researchen
dc.subjectbiomedicineen
dc.subjectBrazilen
dc.subjectclinical researchen
dc.subjectdiagnostic procedureen
dc.subjectdrug designen
dc.subjectdrug developmenten
dc.subjecteducation programen
dc.subjectfundingen
dc.subjecthealth practitioneren
dc.subjecthumanen
dc.subjectinformation processingen
dc.subjectneglected diseaseen
dc.subjectnonhumanen
dc.subjectpriority journalen
dc.subjecttoxinologyen
dc.subjecttranslational researchen
dc.subjecttropicsen
dc.subjectAnimaliaen
dc.titleA success in Toxinology translational research in Brazil: Bridging the gapen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Tropical Diseases and Image Diagnosis Botucatu Medical School São Paulo State University (UNESP - Univ. Estadual Paulista)-
dc.description.affiliationClinical Research Unit (UPECLIN) Botucatu Medical School UNESP - Univ. Estadual Paulista-
dc.description.affiliationCentre for the Study of Venoms and Venomous Animals (CEVAP) UNESP - Univ. Estadual Paulista-
dc.description.affiliationDepartment of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University-
dc.description.affiliationUnespDepartment of Tropical Diseases and Image Diagnosis Botucatu Medical School São Paulo State University (UNESP - Univ. Estadual Paulista)-
dc.description.affiliationUnespClinical Research Unit (UPECLIN) Botucatu Medical School UNESP - Univ. Estadual Paulista-
dc.description.affiliationUnespCentre for the Study of Venoms and Venomous Animals (CEVAP) UNESP - Univ. Estadual Paulista-
dc.description.affiliationUnespDepartment of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University-
dc.identifier.doi10.1016/j.toxicon.2013.01.003-
dc.identifier.wosWOS:000320836100008-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84878478208.pdf-
dc.relation.ispartofToxicon-
dc.identifier.scopus2-s2.0-84878478208-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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