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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/75798
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dc.contributor.authorLeite, Bruna-
dc.contributor.authorGomes, Fernanda-
dc.contributor.authorTeixeira, Pilar-
dc.contributor.authorSouza, Clovis-
dc.contributor.authorPizzolitto, Elisabeth-
dc.contributor.authorOliveira, Rosário-
dc.date.accessioned2014-05-27T11:29:49Z-
dc.date.accessioned2016-10-25T18:50:34Z-
dc.date.available2014-05-27T11:29:49Z-
dc.date.available2016-10-25T18:50:34Z-
dc.date.issued2013-07-01-
dc.identifierhttp://dx.doi.org/10.1097/MJT.0b013e318209e17b-
dc.identifier.citationAmerican Journal of Therapeutics, v. 20, n. 4, p. 322-328, 2013.-
dc.identifier.issn1075-2765-
dc.identifier.issn1536-3686-
dc.identifier.urihttp://hdl.handle.net/11449/75798-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75798-
dc.description.abstractMedical device-associated infections caused by Staphylococcus epidermidis usually involve biofilm formation and its eradication is particularly challenging. Although rifampicin has been proving to be one of the most effective antibiotics against S. epidermidis biofilms, its use as a single agent can lead to the acquisition of resistance. Therefore, we assessed the combined effect of rifampicin with N-acetylcysteine (NAC) known by its mucolytic effect, in the control of S. epidermidis biofilms. Biofilms of 2 S. epidermidis strains (9142 and 1457) were treated with 1× minimum inhibitory concentration (4 mg/mL) and 10× minimum inhibitory concentration (40 mg/mL) of NAC and 10 mg/L (peak serum) of rifampicin alone and in combination. NAC at 40 mg/L alone or in combination with rifampicin (10 mg/L) significantly reduced (4 log 10) the number of biofilm cells. Considering their different modes of action, the association of NAC with rifampicin constitutes a promising therapeutic strategy in the treatment of infections associated to S. epidermidis biofilms. © 2013 Lippincott Williams & Wilkins.en
dc.format.extent322-328-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectBiofilm-
dc.subjectN-acetylcysteine-
dc.subjectPlanktonic cells-
dc.subjectRifampicin-
dc.subjectStaphylococcus epidermidis-
dc.subjectacetylcysteine-
dc.subjectmucolytic agent-
dc.subjectrifampicin-
dc.subjectbacterial strain-
dc.subjectbiofilm-
dc.subjectcontrolled study-
dc.subjectdevice infection-
dc.subjectdrug effect-
dc.subjectminimum inhibitory concentration-
dc.subjectmucolysis-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.titleStaphylococcus epidermidis biofilms control by N-acetylcysteine and rifampicinen
dc.typeoutro-
dc.contributor.institutionUniversity of Minho-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationIBB-Institute for Biotechnology and Bioengineering Centre of Biological Engineering University of Minho, Campus de Gualtar, 4710-057, Braga-
dc.description.affiliationDepartment of Biotechnology Federal University of São Carlos, São Carlos-
dc.description.affiliationFaculty of Pharmaceutical Sciences São Paulo State University, Araraquara-
dc.description.affiliationUnespFaculty of Pharmaceutical Sciences São Paulo State University, Araraquara-
dc.identifier.doi10.1097/MJT.0b013e318209e17b-
dc.identifier.wosWOS:000321982100003-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAmerican Journal of Therapeutics-
dc.identifier.scopus2-s2.0-84880778397-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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