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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7582
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dc.contributor.authorBach-Elias, M.-
dc.contributor.authorBahia, D.-
dc.contributor.authorTeixeira, D. C.-
dc.contributor.authorCicarelli, RMB-
dc.date.accessioned2014-05-20T13:24:27Z-
dc.date.accessioned2016-10-25T16:45:09Z-
dc.date.available2014-05-20T13:24:27Z-
dc.date.available2016-10-25T16:45:09Z-
dc.date.issued1998-10-01-
dc.identifierhttp://dx.doi.org/10.1007/s004360050490-
dc.identifier.citationParasitology Research. New York: Springer Verlag, v. 84, n. 10, p. 796-799, 1998.-
dc.identifier.issn0044-3255-
dc.identifier.urihttp://hdl.handle.net/11449/7582-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7582-
dc.description.abstractWe investigated the possibility that Chagas' patients develop an autoimmune response to human UsnRNPs (small nuclear ribonucleoprotein) or Sm epitopes. Using purified human UsnRNPs, we detected anti-human UsnRNPs antibodies in sera from patients suffering from Chagas' disease. The antibodies it-ere also detected using peptide enzyme-linked immunosorbent assays containing the Sm-motif 1 domain. The latter technique showed that 61% (31/51) of the Chagas' patients' sera contained antibodies against Sm-motif I. The detection of anti-UsnRNPs autoantibodies in Chagas patients' sera strongly encourages further studies using animal models to determine how these autoantibodies appear.en
dc.format.extent796-799-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.titlePresence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' seraen
dc.typeoutro-
dc.contributor.institutionCid-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationCid, CSIC, E-08034 Barcelona, Spain-
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Araraquara, SP, Brazil-
dc.identifier.doi10.1007/s004360050490-
dc.identifier.wosWOS:000076197400006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofParasitology Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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