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The action of aminoguanidine on the liver of trained diabetic rats
Universidade Estadual Paulista (UNESP)
Background: This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques.Methods: The rats used in this study were divided into five groups: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine.Results: The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels.Conclusion: Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin. © 2013 e Nico et al.; licensee BioMed Central Ltd.
Issue Date: 
Journal of Diabetes and Metabolic Disorders, v. 12, n. 1, 2013.
  • Aminoguanidine
  • Diabetes type 1
  • Liver
  • Physical exercises
  • Rats
  • aminoguanidine
  • polysaccharide
  • animal experiment
  • animal model
  • animal tissue
  • cellular distribution
  • controlled study
  • cytoplasm
  • diabetes mellitus
  • exercise
  • insulin dependent diabetes mellitus
  • Kupffer cell
  • liver
  • liver blood vessel
  • liver congestion
  • liver histology
  • liver hypertrophy
  • male
  • nonhuman
  • rat
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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