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http://acervodigital.unesp.br/handle/11449/75935
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DC Field | Value | Language |
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dc.contributor.author | e Nico, Edmara Tereza Meira | - |
dc.contributor.author | de Oliveira, Patrícia Rosa | - |
dc.contributor.author | de Souza, Leonardo Peres | - |
dc.contributor.author | Pereira, Franco Dani Campos | - |
dc.contributor.author | Delbin, Maria Andréia | - |
dc.contributor.author | Zanesco, Angelina | - |
dc.contributor.author | Camargo-Mathias, Maria Izabel | - |
dc.date.accessioned | 2014-05-27T11:29:55Z | - |
dc.date.accessioned | 2016-10-25T18:51:04Z | - |
dc.date.available | 2014-05-27T11:29:55Z | - |
dc.date.available | 2016-10-25T18:51:04Z | - |
dc.date.issued | 2013-07-09 | - |
dc.identifier | http://dx.doi.org/10.1186/2251-6581-12-40 | - |
dc.identifier.citation | Journal of Diabetes and Metabolic Disorders, v. 12, n. 1, 2013. | - |
dc.identifier.issn | 2251-6581 | - |
dc.identifier.uri | http://hdl.handle.net/11449/75935 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/75935 | - |
dc.description.abstract | Background: This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques.Methods: The rats used in this study were divided into five groups: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine.Results: The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels.Conclusion: Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin. © 2013 e Nico et al.; licensee BioMed Central Ltd. | en |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | Aminoguanidine | - |
dc.subject | Diabetes type 1 | - |
dc.subject | Liver | - |
dc.subject | Physical exercises | - |
dc.subject | Rats | - |
dc.subject | aminoguanidine | - |
dc.subject | polysaccharide | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.subject | cellular distribution | - |
dc.subject | controlled study | - |
dc.subject | cytoplasm | - |
dc.subject | diabetes mellitus | - |
dc.subject | exercise | - |
dc.subject | insulin dependent diabetes mellitus | - |
dc.subject | Kupffer cell | - |
dc.subject | liver | - |
dc.subject | liver blood vessel | - |
dc.subject | liver congestion | - |
dc.subject | liver histology | - |
dc.subject | liver hypertrophy | - |
dc.subject | male | - |
dc.subject | nonhuman | - |
dc.subject | rat | - |
dc.title | The action of aminoguanidine on the liver of trained diabetic rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199 | - |
dc.description.affiliationUnesp | UNESP-University Estadual Paulista, Avenida 24 A, 1515, 13506-900, Rio Claro, SP CP 199 | - |
dc.identifier.doi | 10.1186/2251-6581-12-40 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | 2-s2.0-84882587429.pdf | - |
dc.relation.ispartof | Journal of Diabetes and Metabolic Disorders | - |
dc.identifier.scopus | 2-s2.0-84882587429 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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