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dc.contributor.authorViali, Wesley Renato-
dc.contributor.authorDa Silva Nunes, Eloiza-
dc.contributor.authorDos Santos, Caio Carvalho-
dc.contributor.authorDa Silva, Sebastião William-
dc.contributor.authorAragón, Fermin Herrera-
dc.contributor.authorCoaquira, José Antonio Huamaní-
dc.contributor.authorMorais, Paulo César-
dc.contributor.authorJafelicci Júnior, Miguel-
dc.identifier.citationJournal of Nanoparticle Research, v. 15, n. 8, 2013.-
dc.description.abstractIn this study, we report on a new route of PEGylation of superparamagnetic iron oxide nanoparticles (SPIONs) by polycondensation reaction with carboxylate groups. Structural and magnetic characterizations were performed by X-ray diffractometry (XRD), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometry (VSM). The XRD confirmed the spinel structure with a crystallite average diameter in the range of 3.5-4.1 nm in good agreement with the average diameter obtained by TEM (4.60-4.97 nm). The TGA data indicate the presence of PEG attached onto the SPIONs' surface. The SPIONs were superparamagnetic at room temperature with saturation magnetization (M S) from 36.7 to 54.1 emu/g. The colloidal stability of citrate- and PEG-coated SPIONs was evaluated by means of dynamic light scattering measurements as a function of pH, ionic strength, and nature of dispersion media (phosphate buffer and cell culture media). Our findings demonstrated that the PEG polymer chain length plays a key role in the coagulation behavior of the Mag-PEG suspensions. The excellent colloidal stability under the extreme conditions we evaluated, such as high ionic strength, pH near the isoelectric point, and cell culture media, revealed that suspensions comprising PEG-coated SPION, with PEG of molecular weight 600 and above, present steric stabilization attributed to the polymer chains attached onto the surface of SPIONs. © 2013 Springer Science+Business Media Dordrecht.en
dc.subjectColloidal stability-
dc.subjectIron oxide-
dc.subjectMagnetic fluid-
dc.subjectSurface modification-
dc.subjectColloidal Stability-
dc.subjectDynamic light scattering measurement-
dc.subjectMagnetic characterization-
dc.subjectPolycondensation reactions-
dc.subjectPolymer chain length-
dc.subjectSuperparamagnetic iron oxide nanoparticles-
dc.subjectVibrating sample magnetometry-
dc.subjectCell culture-
dc.subjectChain length-
dc.subjectIonic strength-
dc.subjectIron oxides-
dc.subjectMagnetic fluids-
dc.subjectPlastic coatings-
dc.subjectPolyethylene glycols-
dc.subjectSurface treatment-
dc.subjectThermogravimetric analysis-
dc.subjectTransmission electron microscopy-
dc.subjectX ray diffraction analysis-
dc.subjectSuspensions (fluids)-
dc.subjectcitric acid-
dc.subjectsuperparamagnetic iron oxide nanoparticle-
dc.subjectcell culture-
dc.subjectcolloidal stability-
dc.subjectionic strength-
dc.subjectisoelectric point-
dc.subjectlight scattering-
dc.subjectmolecular weight-
dc.subjectphysical phenomena-
dc.subjectpriority journal-
dc.subjectroom temperature-
dc.subjecttransmission electron microscopy-
dc.subjectX ray diffraction-
dc.titlePEGylation of SPIONs by polycondensation reactions: A new strategy to improve colloidal stability in biological mediaen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de Brasília (UnB)-
dc.contributor.institutionHuazhong University of Science and Technology-
dc.description.affiliationLaboratório de Materiais Magnéticos e Coloides Departamento de Físico-química Universidade Estadual Paulista, Araraquara SP 14801-970-
dc.description.affiliationInstituto de Física Núcleo de Física Aplicada Universidade de Brasília, Brasília DF 70910-900-
dc.description.affiliationDepartment of Control Science and Engineering Huazhong University of Science and Technology, Wuhan 430074-
dc.description.affiliationUnespLaboratório de Materiais Magnéticos e Coloides Departamento de Físico-química Universidade Estadual Paulista, Araraquara SP 14801-970-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Nanoparticle Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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