Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug

Silva, M.; Ricelli, N. L.; El Seoud, O.; Valentim, C. S.; Ferreira, A. G.; Sato, D. N.; Leitel, CQF; Ferreira, E. I.

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7598

Title:

Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)
Universidade Federal de São Carlos (UFSCar)
Instituto Adolfo Lutz (IAL)

ISSN:

0365-6233

Abstract:

Pyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and micelle diameter. The CMC was found by observing the solubility of Sudan III in Poly(ethylene glycol)-poly(pyrazinamidomethyl aspartate) copolymer (PEG-PASP-PZA) solutions. The mean diameter of PEG-PASP-PZA micelles, obtained by analyzing the dynamic light-scattering data, was 78.2 nm. The PEG-PASP-PZA derivative, when assayed for anti-Mycobacterium activity, exhibited stronger activity than the simple drug.

Issue Date:

1-Jun-2006

Citation:

Archiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 339, n. 6, p. 283-290, 2006.

Time Duration:

283-290

Publisher:

Wiley-Blackwell

Keywords:

pyrazinamide
micelle-forming polymer
tuberculostatic prodrug

Source:

http://dx.doi.org/10.1002/ardp.200500039

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/7598

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