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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7598
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dc.contributor.authorSilva, M.-
dc.contributor.authorRicelli, N. L.-
dc.contributor.authorEl Seoud, O.-
dc.contributor.authorValentim, C. S.-
dc.contributor.authorFerreira, A. G.-
dc.contributor.authorSato, D. N.-
dc.contributor.authorLeitel, CQF-
dc.contributor.authorFerreira, E. I.-
dc.date.accessioned2014-05-20T13:24:28Z-
dc.date.accessioned2016-10-25T16:45:11Z-
dc.date.available2014-05-20T13:24:28Z-
dc.date.available2016-10-25T16:45:11Z-
dc.date.issued2006-06-01-
dc.identifierhttp://dx.doi.org/10.1002/ardp.200500039-
dc.identifier.citationArchiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 339, n. 6, p. 283-290, 2006.-
dc.identifier.issn0365-6233-
dc.identifier.urihttp://hdl.handle.net/11449/7598-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7598-
dc.description.abstractPyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and micelle diameter. The CMC was found by observing the solubility of Sudan III in Poly(ethylene glycol)-poly(pyrazinamidomethyl aspartate) copolymer (PEG-PASP-PZA) solutions. The mean diameter of PEG-PASP-PZA micelles, obtained by analyzing the dynamic light-scattering data, was 78.2 nm. The PEG-PASP-PZA derivative, when assayed for anti-Mycobacterium activity, exhibited stronger activity than the simple drug.en
dc.format.extent283-290-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectpyrazinamidept
dc.subjectmicelle-forming polymerpt
dc.subjecttuberculostatic prodrugpt
dc.titlePotential tuberculostatic agent: Micelle-forming pyrazinamide prodrugen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801210 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Inst Quim, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Araraquara, SP, Brazil-
dc.description.affiliationUniv Fed Sao Carlos, Ctr Ciências Exatas & Tecnol, São Paulo, Brazil-
dc.description.affiliationInst Adolfo Lutz Registro, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801210 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Araraquara, SP, Brazil-
dc.identifier.doi10.1002/ardp.200500039-
dc.identifier.wosWOS:000238395100001-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArchiv Der Pharmazie-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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