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dc.contributor.authorDamasceno, Débora Cristina-
dc.contributor.authorSinzato, Yuri K.-
dc.contributor.authorBueno, Aline-
dc.contributor.authorDallaqua, Bruna-
dc.contributor.authorLima, Paula H.-
dc.contributor.authorCalderon, Iracema de Mattos Paranhos-
dc.contributor.authorRudge, Marilza Vieira Cunha-
dc.contributor.authorCampos, Kleber Eduardo de-
dc.identifier.citationObesity, v. 21, n. 8, p. 1596-1601, 2013.-
dc.description.abstractObjective Experimental studies have shown that exposure to cigarette smoke has negative effects on lipid metabolism and oxidative stress status. Cigarette smoke exposure in nonpregnant and pregnant rats causes significant genotoxicity (DNA damage). However, no previous studies have directly evaluated the effects of obesity or the association between obesity and cigarette smoke exposure on genotoxicity. Therefore, the aim of the present investigation was to evaluate DNA damage levels, oxidative stress status and lipid profiles in obese Wistar rats exposed to cigarette smoke. Design and Methods Female rats subcutaneously (sc) received a monosodium glutamate solution or vehicle (control) during the neonatal period to induce obesity. The rats were randomly distributed into three experimental groups: control, obese exposed to filtered air, and obese exposed to tobacco cigarette smoke. After a 2-month exposure period, the rats were anesthetized and killed to obtain blood samples for genotoxicity, lipid profile, and oxidative stress status analyses. Results The obese rats exposed to tobacco cigarette smoke presented higher DNA damage, triglycerides, total cholesterol, free fatty acids, VLDL-c, HDL-c, and LDL-c levels compared to control and obese rats exposed to filtered air. Both obese groups showed reduced SOD activity. These results showed that cigarette smoke enhanced the effects of obesity. Conclusion In conclusion, the association between obesity and cigarette smoke exposure exacerbated the genotoxicity, negatively impacted the biochemical profile and antioxidant defenses and caused early glucose intolerance. Thus, the changes caused by cigarette smoke exposure can trigger the earlier onset of metabolic disorders associated with obesity, such as diabetes and metabolic syndrome. Copyright © 2012 The Obesity Society.en
dc.subjectfatty acid-
dc.subjectglutamate sodium-
dc.subjectglutathione peroxidase-
dc.subjecthigh density lipoprotein cholesterol-
dc.subjectlow density lipoprotein cholesterol-
dc.subjectsuperoxide dismutase-
dc.subjectthiobarbituric acid reactive substance-
dc.subjectvery low density lipoprotein cholesterol-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectblood sampling-
dc.subjectcholesterol blood level-
dc.subjectcontrolled study-
dc.subjectDNA damage-
dc.subjectenzyme activity-
dc.subjectfatty acid blood level-
dc.subjectglucose intolerance-
dc.subjectlipid metabolism-
dc.subjectoxidative stress-
dc.subjectprotein expression-
dc.subjectprotein function-
dc.subjecttriacylglycerol blood level-
dc.subjectNicotiana tabacum-
dc.subjectRattus norvegicus-
dc.titleMetabolic profile and genotoxicity in obese rats exposed to cigarette smokeen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)-
dc.description.affiliationDepartment of Gynecology and Obstetrics Botucatu Medical School Unesp/Univ. Estadual Paulista, São Paulo State-
dc.description.affiliationPhysiology Department University Center of Araguaia Mato Grosso Federal University (UFMT), Mato Grosso Barra do Garças-
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Botucatu Medical School Unesp/Univ. Estadual Paulista, São Paulo State-
dc.rights.accessRightsAcesso restrito-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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