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dc.contributor.authorBiselli, P. J. C.-
dc.contributor.authorJuvenale, M.-
dc.contributor.authorMendes-Giannini, Maria José Soares-
dc.contributor.authorDuarte, A. J. S.-
dc.contributor.authorBenard, G.-
dc.date.accessioned2014-05-20T13:24:29Z-
dc.date.accessioned2016-10-25T16:45:12Z-
dc.date.available2014-05-20T13:24:29Z-
dc.date.available2016-10-25T16:45:12Z-
dc.date.issued2001-12-01-
dc.identifierhttp://dx.doi.org/10.1080/mmy.39.6.475.478-
dc.identifier.citationMedical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 39, n. 6, p. 475-478, 2001.-
dc.identifier.issn1369-3786-
dc.identifier.urihttp://hdl.handle.net/11449/7609-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7609-
dc.description.abstractParacoccidioidomycosis (PCM) has two main clinical presentations, a chronic form (CF) and an acute, more severe form (AF). The AF is associated with a more marked dysfunction of the patient's immune response, and a distinct anti-Paracoccidioides brasiliensis immunoglobulin (Ig)A and IgG antibody subclass expression, compared with that seen in the CF. In this study we investigated the presence of IgE antibodies against the main P. brasiliensis antigen (a 43-kDa molecule) in the serum of PCM patients using an enzyme-linked immunosorbent assay. We found that 100% of the AF patients (n = 16) produced IgE antibodies, mostly at high levels, whereas only 9 (27%) out of 33 CF patients produced this isotype. Interestingly, these nine patients presented higher serological titers on the counter-immunoelectrophoresis assays than did those who did not produce IgE; a finding that suggests that they had a relatively more severe disease. As IgE is a characteristic feature of the AF patients, and switching to a positive IgE response is dependent on interleukin-4, our results support the notion that the relatively more severe impairment of cellular immunity in the AF is probably related to a Th-2 pattern of immune response.en
dc.format.extent475-478-
dc.language.isoeng-
dc.publisherB I O S Scientific Publishers Ltd-
dc.sourceWeb of Science-
dc.subjectantibody responsept
dc.subjectIgEpt
dc.subjectParacoccidioides brasiliensispt
dc.subjectparacoccidioidomycosispt
dc.titleIgE antibody response to the main antigenic component of Paracoccidioides brasiliensis in patients with paracoccidioidomycosisen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUSP, Fac Med, Lab Alergia & Imunol Clin & Expt LIM56, BR-01246903 São Paulo, Brazil-
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Dept Anal Clin, Arararquara, Brazil-
dc.description.affiliationHosp Clin FMUSP, Clin Doencas Infecciosas & Parasitarias, São Paulo, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Dept Anal Clin, Arararquara, Brazil-
dc.identifier.doi10.1080/mmy.39.6.475.478-
dc.identifier.wosWOS:000172929200002-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMedical Mycology-
dc.identifier.orcid0000-0002-8059-0826-
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