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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76124
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dc.contributor.authorJaldin, Rodrigo Gibin-
dc.contributor.authorCastardelli, Édson-
dc.contributor.authorPerobelli, Juliana Elaine-
dc.contributor.authorYoshida, Winston Bonetti-
dc.contributor.authorDe Castro Rodrigues, Antônio-
dc.contributor.authorSequeira, Júlio Lopes-
dc.contributor.authorPaiva, Sergio Alberto Rupp de-
dc.date.accessioned2014-05-27T11:30:05Z-
dc.date.accessioned2016-10-25T18:51:57Z-
dc.date.available2014-05-27T11:30:05Z-
dc.date.available2016-10-25T18:51:57Z-
dc.date.issued2013-08-01-
dc.identifierhttp://dx.doi.org/10.1016/j.avsg.2013.03.002-
dc.identifier.citationAnnals of Vascular Surgery, v. 27, n. 6, p. 791-800, 2013.-
dc.identifier.issn0890-5096-
dc.identifier.issn1615-5947-
dc.identifier.urihttp://hdl.handle.net/11449/76124-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76124-
dc.description.abstractBackground: Smoking is the most relevant environmental factor that affects the development of aortic aneurysm. Smokers have elevated levels of elastase activity in the arterial wall, which leads to weakening of the aorta. The aim of this study was to verify whether cigarette smoke exposure itself is capable of altering the aortic wall. Methods: Forty-eight Wistar rats were divided into 2-, 4-, and 6-month experimental periods and into 2 groups: smokers (submitted to smoke exposure at a rate of 40 cigarettes/day) and nonsmokers. At the end of the experimental periods, the aortas were removed and cross-sectioned to obtain histologic specimens for light microscopic and morphometric analyses. The remaining longitudinal segments were stretched to rupture and mechanical parameters were determined. Results: A degenerative process (i.e., a reduction in elastic fibers, the loss of lamellar arrangement, and a reduction of smooth muscle cells) was observed, and this effect was proportional in intensity to the period of tobacco exposure. We observed a progressive reduction in the yield point of the thoracic aorta over time (P < 0.05). There was a decrease in stiffness (P < 0.05) and in failure load (P < 0.05) at 6 months in the abdominal aorta of rats in the smoking group. Conclusions: Chronic exposure to tobacco smoke can affect the mechanical properties of the aorta and can also provoke substantial structural changes of the arterial wall. © 2013 Elsevier Inc. All rights reserved.en
dc.format.extent791-800-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectcigarette smoke-
dc.subjectabdominal aorta-
dc.subjectanimal experiment-
dc.subjectanimal tissue-
dc.subjectaorta wall-
dc.subjectarterial stiffness-
dc.subjectbiomechanics-
dc.subjectcontrolled study-
dc.subjectenvironmental exposure-
dc.subjectheart muscle compliance-
dc.subjecthistology-
dc.subjectmale-
dc.subjectmathematical model-
dc.subjectmorphology-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectrat-
dc.subjectsmooth muscle fiber-
dc.subjecttensile strength-
dc.subjectthoracic aorta-
dc.titleMorphologic and biomechanical changes of thoracic and abdominal aorta in a rat model of cigarette smoke exposureen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade do Sagrado Coração (USC)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversity School of Veterinary Medicine-
dc.description.affiliationDepartment of Surgery and Orthopaedics São Paulo State University Medical School, Botucatu-
dc.description.affiliationDepartment of Internal Medicine São Paulo State University Medical School, Botucatu-
dc.description.affiliationDepartment of Basic Science Sagrado Coracao University, Bauru-
dc.description.affiliationDepartment of Biological Sciences University of São Paulo School of Odontology, Bauru-
dc.description.affiliationDepartment of Veterinary Pathology São Paulo State University School of Veterinary Medicine, Botucatu-
dc.description.affiliationUnespDepartment of Surgery and Orthopaedics São Paulo State University Medical School, Botucatu-
dc.description.affiliationUnespDepartment of Internal Medicine São Paulo State University Medical School, Botucatu-
dc.description.affiliationUnespDepartment of Veterinary Pathology São Paulo State University School of Veterinary Medicine, Botucatu-
dc.identifier.doi10.1016/j.avsg.2013.03.002-
dc.identifier.wosWOS:000322806200016-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAnnals of Vascular Surgery-
dc.identifier.scopus2-s2.0-84880719639-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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