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Açai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
  • 0278-6915
  • 1873-6351
This study investigated the protective effect of spray-dried açaí powder (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4. weeks of DMH administrations, the groups were fed with standard diet, a diet containing 2.5% or 5.0% AP or a diet containing 0.2% N-acetylcysteine (NAC) for 10. weeks, using aberrant crypt foci (ACF) as the endpoint. Additionally, two groups were fed with standard diet or a diet containing 5.0% AP for 20. weeks, using colon tumors as the endpoint. In ACF assay, a reduction in the number of aberrant crypts (ACs) and ACF (1-3 AC) were observed in the groups fed with 5.0% AP (37% AC and 47% ACF inhibition, p=. 0.036) and 0.2% NAC (39% AC and 41% ACF inhibition, p=. 0.042). In tumor assay, a reduction in the number of invasive tumors (p<. 0.005) and tumor multiplicity (p=. 0.001) was observed in the group fed with 5.0% AP. Also, a reduction in tumor Ki-67 cell proliferation (p=. 0.003) and net growth index (p=. 0.001) was observed in the group fed with 5.0% AP. Therefore the findings of this study indicate that AP feeding may reduce the development of chemically-induced rat colon carcinogenesis. © 2013 Elsevier Ltd.
Issue Date: 
Food and Chemical Toxicology, v. 58, p. 68-76.
Time Duration: 
  • Aberrant crypt foci
  • Açaí pulp
  • Colon carcinogenesis
  • Spray-dry
  • acetylcysteine
  • beta catenin
  • caspase 3
  • connexin 43
  • dimethylhydrazine
  • Euterpe oleracea extract
  • Ki 67 antigen
  • plant extract
  • unclassified drug
  • animal cell
  • animal experiment
  • animal model
  • animal tissue
  • apoptosis
  • Arecaceae
  • cancer inhibition
  • cell proliferation
  • colon cancer
  • colon carcinogenesis
  • controlled study
  • Euterpe oleracea
  • fluid intake
  • food intake
  • intestine crypt
  • male
  • nonhuman
  • powder
  • protein expression
  • rat
  • spray drying
  • treatment duration
  • tumor growth
  • weight gain
Access Rights: 
Acesso aberto
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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