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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76129
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dc.contributor.authorFragoso, Mariana F.-
dc.contributor.authorRomualdo, Guilherme R.-
dc.contributor.authorRibeiro, Daniel A.-
dc.contributor.authorBarbisan, Luis F.-
dc.date.accessioned2014-05-27T11:30:05Z-
dc.date.accessioned2016-10-25T18:51:58Z-
dc.date.available2014-05-27T11:30:05Z-
dc.date.available2016-10-25T18:51:58Z-
dc.date.issued2013-08-01-
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2013.04.011-
dc.identifier.citationFood and Chemical Toxicology, v. 58, p. 68-76.-
dc.identifier.issn0278-6915-
dc.identifier.issn1873-6351-
dc.identifier.urihttp://hdl.handle.net/11449/76129-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76129-
dc.description.abstractThis study investigated the protective effect of spray-dried açaí powder (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4. weeks of DMH administrations, the groups were fed with standard diet, a diet containing 2.5% or 5.0% AP or a diet containing 0.2% N-acetylcysteine (NAC) for 10. weeks, using aberrant crypt foci (ACF) as the endpoint. Additionally, two groups were fed with standard diet or a diet containing 5.0% AP for 20. weeks, using colon tumors as the endpoint. In ACF assay, a reduction in the number of aberrant crypts (ACs) and ACF (1-3 AC) were observed in the groups fed with 5.0% AP (37% AC and 47% ACF inhibition, p=. 0.036) and 0.2% NAC (39% AC and 41% ACF inhibition, p=. 0.042). In tumor assay, a reduction in the number of invasive tumors (p<. 0.005) and tumor multiplicity (p=. 0.001) was observed in the group fed with 5.0% AP. Also, a reduction in tumor Ki-67 cell proliferation (p=. 0.003) and net growth index (p=. 0.001) was observed in the group fed with 5.0% AP. Therefore the findings of this study indicate that AP feeding may reduce the development of chemically-induced rat colon carcinogenesis. © 2013 Elsevier Ltd.en
dc.format.extent68-76-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAberrant crypt foci-
dc.subjectAçaí pulp-
dc.subjectColon carcinogenesis-
dc.subjectSpray-dry-
dc.subjectacetylcysteine-
dc.subjectbeta catenin-
dc.subjectcaspase 3-
dc.subjectconnexin 43-
dc.subjectdimethylhydrazine-
dc.subjectEuterpe oleracea extract-
dc.subjectKi 67 antigen-
dc.subjectplant extract-
dc.subjectunclassified drug-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectapoptosis-
dc.subjectArecaceae-
dc.subjectcancer inhibition-
dc.subjectcell proliferation-
dc.subjectcolon cancer-
dc.subjectcolon carcinogenesis-
dc.subjectcontrolled study-
dc.subjectEuterpe oleracea-
dc.subjectfluid intake-
dc.subjectfood intake-
dc.subjectintestine crypt-
dc.subjectmale-
dc.subjectnonhuman-
dc.subjectpowder-
dc.subjectprotein expression-
dc.subjectrat-
dc.subjectspray drying-
dc.subjecttreatment duration-
dc.subjecttumor growth-
dc.subjectweight gain-
dc.titleAçai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesisen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUNESP - Univ. Estadual Paulista School of Medicine, Botucatu 18618-970, SP-
dc.description.affiliationUNESP - Univ. Estadual Paulista Institute of Biosciences Department of Morphology, Botucatu 18618-970, SP-
dc.description.affiliationUNIFESP Federal University of Sao Paulo Department of Biosciences, 11060-001 Santos, SP-
dc.description.affiliationUnespUNESP - Univ. Estadual Paulista School of Medicine, Botucatu 18618-970, SP-
dc.description.affiliationUnespUNESP - Univ. Estadual Paulista Institute of Biosciences Department of Morphology, Botucatu 18618-970, SP-
dc.identifier.doi10.1016/j.fct.2013.04.011-
dc.identifier.wosWOS:000322099100010-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84877654261.pdf-
dc.relation.ispartofFood and Chemical Toxicology-
dc.identifier.scopus2-s2.0-84877654261-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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