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The Genome of Anopheles darlingi, the main neotropical malaria vector
  • University of California Irvine
  • Broad Institute of Harvard and Massachusetts
  • Laboratório Nacional de Computação Científica
  • Universidade Estadual Paulista (UNESP)
  • Universidade Federal de Santa Maria (UFSM)
  • Universidade Federal do Rio Grande do Sul (UFRGS)
  • Universidade Federal de Minas Gerais (UFMG)
  • University of Massachusetts
  • Fundação Oswaldo Cruz (FIOCRUZ)
  • Universidade Federal de Santa Catarina (UFSC)
  • Universidade Estadual do Ceará (UECE)
  • Universidade Federal do Piauí (UFPI)
  • Universidade Federal do Pará (UFPA)
  • University of Connecticut Health Center
  • J. Craig Venter Institute
  • Universidade Estadual de Campinas (UNICAMP)
  • Universidade Federal de Viçosa (UFV)
  • Universidade Federal do Amazonas (UFAM)
  • Universidade Federal de Goiás (UFG)
  • Universidade Federal da Paraíba (UFPB)
  • Universidade Estadual de Londrina (UEL)
  • Universidade Federal do Rio de Janeiro (UFRJ)
  • Instituto Nacional de Pesquisas da Amazônia (INPA)
  • Laboratório Nacional de Ciência e Tecnologia do Bioetanol (CTBE)
  • Universidade de São Paulo (USP)
  • National Institutes of Health (NIH)
  • Universidade Federal do Rio Grande do Norte (UFRN)
  • Universidade de Brasília (UnB)
  • Universidade Federal Rural de Pernambuco (UFRPE)
  • Universidade Católica de Brasília (UCB)
  • Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
  • 0305-1048
  • 1362-4962
  • National Institute of Allergy and Infectious Diseases
  • National Institutes of Health
  • Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vectorhuman and vectorparasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at darlingi. © 2013 The Author(s).
Issue Date: 
Nucleic Acids Research, v. 41, n. 15, p. 7387-7400, 2013.
Time Duration: 
  • Anopheles
  • Anopheles darlingi
  • Anopheles gambiae
  • circadian rhythm
  • female
  • gene identification
  • gene sequence
  • genetic conservation
  • genetic marker
  • genome analysis
  • genome size
  • indel mutation
  • insect genetics
  • insecticide resistance
  • male
  • nonhuman
  • priority journal
  • sequence homology
  • single nucleotide polymorphism
  • synteny
  • transposon
  • xenobiotic metabolism
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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