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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76196
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dc.contributor.authorBalderramas, Helanderson A.-
dc.contributor.authorRibeiro, Orlando G.-
dc.contributor.authorSoares, Ângela Maria Victoriano de Campos-
dc.contributor.authorOliveira, Silvio L.-
dc.date.accessioned2014-05-27T11:30:07Z-
dc.date.accessioned2016-10-25T18:52:07Z-
dc.date.available2014-05-27T11:30:07Z-
dc.date.available2016-10-25T18:52:07Z-
dc.date.issued2013-08-01-
dc.identifierhttp://dx.doi.org/10.3109/13693786.2013.777163-
dc.identifier.citationMedical Mycology, v. 51, n. 6, p. 625-634, 2013.-
dc.identifier.issn1369-3786-
dc.identifier.issn1460-2709-
dc.identifier.urihttp://hdl.handle.net/11449/76196-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76196-
dc.description.abstractParacoccidioidomycosis is a human systemic mycosis caused by the fungus Paracoccidioides brasiliensis. The mechanisms involved in innate immune response to this fungus are not fully elucidated. Leukotrienes are known to be critical for the clearance of various microorganisms, mainly by mediating the microbicidal function of phagocytes. We investigated the involvement of leukotriene B4 in the early stages of experimental paracoccidioidomycosis, which was induced by intratracheal inoculation of the fungus in selected mouse lines. The mouse lines utilized were produced through bi-directional phenotypic selection, endowed with maximal or minimal acute inflammatory reactivity, and designated AIRmax and AIRmin, respectively. AIRmax mice were more resistant to the infection, which was demonstrated by reduced lung fungal loads. However, the two lines produced similar amounts of leukotriene B4, and pharmacological inhibition of this mediator provoked similar fungal load increases in the two lines. The lower fungal load in the AIRmax mice was associated with a more effective inflammatory response, which was characterized by enhanced recruitment and activation of phagocytic cells and an increased production of activator cytokines. This process resulted in an increased release of fungicidal molecules and a diminution of fungal load. In both lines, leukotriene production was associated with a protective response in the lung that was consequent to the effect of this eicosanoid on the influx and activation of phagocytes. © 2013 ISHAM.en
dc.format.extent625-634-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAcute inflammation-
dc.subjectCytokines-
dc.subjectLeukotrienes-
dc.subjectParacoccidioides brasiliensis-
dc.subjectgamma interferon-
dc.subjecticosanoid-
dc.subjectinterleukin 10-
dc.subjectleukotriene B4-
dc.subjectnitrous oxide-
dc.subjecttumor necrosis factor alpha-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectcell population-
dc.subjectcontrolled study-
dc.subjectcytokine production-
dc.subjectfungal strain-
dc.subjectfungal viability-
dc.subjectfungus culture-
dc.subjectimmune response-
dc.subjectinflammation-
dc.subjectleukocyte-
dc.subjectlung lavage-
dc.subjectmononuclear cell-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectphagocyte-
dc.subjectphase contrast microscopy-
dc.subjectpolymorphonuclear cell-
dc.subjectSouth American blastomycosis-
dc.subjectstaging-
dc.titleThe role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strainsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInstituto Butantan-
dc.description.affiliationBotucatu School of Medicine Department of Tropical Diseases Universidade Estadual Paulista, UNESP, Bairro: Distrito de Rubião Junior S/N, Botucatu, SP, 18618-000-
dc.description.affiliationDepartment of Microbiology and Immunology Institute of Biosciences Universidade Estadual Paulista (UNESP), São Paulo-
dc.description.affiliationLaboratory of Immunogenetics Butantan Institute, São Paulo-
dc.description.affiliationUnespBotucatu School of Medicine Department of Tropical Diseases Universidade Estadual Paulista, UNESP, Bairro: Distrito de Rubião Junior S/N, Botucatu, SP, 18618-000-
dc.description.affiliationUnespDepartment of Microbiology and Immunology Institute of Biosciences Universidade Estadual Paulista (UNESP), São Paulo-
dc.identifier.doi10.3109/13693786.2013.777163-
dc.identifier.wosWOS:000321790600009-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMedical Mycology-
dc.identifier.scopus2-s2.0-84880309798-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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