You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76292
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCardoso, Ana Paula Ferragut-
dc.contributor.authorIhlaseh Catalano, Shadia Muhammad-
dc.contributor.authorda Rocha, Mitscheli Sanches-
dc.contributor.authorNascimento e Pontes, Merielen Garcia-
dc.contributor.authorCamargo, João Lauro Viana de-
dc.contributor.authorOliveira, Maria Luiza Cotrim Sartor de-
dc.date.accessioned2014-05-27T11:30:11Z-
dc.date.accessioned2016-10-25T18:52:43Z-
dc.date.available2014-05-27T11:30:11Z-
dc.date.available2016-10-25T18:52:43Z-
dc.date.issued2013-08-20-
dc.identifierhttp://dx.doi.org/10.1016/j.tox.2013.07.007-
dc.identifier.citationToxicology, v. 312, n. 1, p. 1-5, 2013.-
dc.identifier.issn0300-483X-
dc.identifier.issn1879-3185-
dc.identifier.urihttp://hdl.handle.net/11449/76292-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76292-
dc.description.abstractDiuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] is a herbicide that induced urothelial tumors in the urinary bladder of Wistar rats fed 2500. ppm during a long-term study. The currently suggested non-genotoxic mode of action (MOA) of diuron encompasses in succession urothelial necrosis induced by direct cytotoxicity, regenerative cell proliferation and sustained urothelial hyperplasia that increases the likelihood of neoplasia development. This study evaluated the dose-response profile of urothelial histological and ultrastructural lesions induced by diuron. Sixty male Wistar rats were fed ad libitum diuron mixed in the diet at 0, 60, 125, 500, 1250, or 2500. ppm for 20 weeks. The incidences of urothelial simple hyperplasia and the cell proliferation index were significantly increased in the diuron-fed 1250 and 2500. ppm groups. By scanning electron microscopy, the incidences and severity of lesions were significantly increased in the 500 and 1250. ppm groups. The incidences of urothelial hyperplasia in the kidney pelvis were significantly increased in the 500, 1250 and 2500. ppm groups. The present study documents the dose-response influence of diuron on the rat urothelium, with a no observed effect level (NOEL) at 125. ppm; 1250. ppm was as effective as 2500. ppm at inducing urothelial lesions. © 2013 Elsevier B.V.en
dc.format.extent1-5-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectCell proliferation-
dc.subjectCytotoxicity-
dc.subjectDiuron-
dc.subjectDose-response-
dc.subjectRat urothelial hyperplasia-
dc.subjectScanning electron microscopy-
dc.subjectdiuron-
dc.subjectanimal tissue-
dc.subjectcell proliferation-
dc.subjectcontrolled study-
dc.subjectdiet-
dc.subjectdose response-
dc.subjecthistopathology-
dc.subjecthyperplasia-
dc.subjectkidney pelvis-
dc.subjectmale-
dc.subjectmucosa-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectrat-
dc.subjectscanning electron microscopy-
dc.subjecturothelium-
dc.subjectweight gain-
dc.titleDose-response of diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] in the urothelial mucosa of Wistar ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationCenter for the Evaluation of the Environmental Impact on Human Health (TOXICAM) Department of Pathology Botucatu Medical School, UNESP - São Paulo State University, Botucatu 18618-970, São Paulo-
dc.description.affiliationUnespCenter for the Evaluation of the Environmental Impact on Human Health (TOXICAM) Department of Pathology Botucatu Medical School, UNESP - São Paulo State University, Botucatu 18618-970, São Paulo-
dc.identifier.doi10.1016/j.tox.2013.07.007-
dc.identifier.wosWOS:000327005300001-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofToxicology-
dc.identifier.scopus2-s2.0-84881496794-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.