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dc.contributor.authorBonacorsi, Cibele-
dc.contributor.authorDa Fonseca, Luiz Marcos-
dc.contributor.authorRaddi, Maria Stella Gonçalves-
dc.contributor.authorKitagawa, Rodrigo Rezende-
dc.contributor.authorVilegas, Wagner-
dc.identifier.citationEvidence-based Complementary and Alternative Medicine, v. 2013.-
dc.description.abstractTen Brazilian medicinal plants used to treat gastritis and ulcers were carefully selected on the basis of ethnopharmacological importance and antiulcerogenic activity previously described. The antioxidant activity of the methanolic extracts was determined in analysis conditions that simulate a real biological activity on inhibition of the oxidative burst induced in neutrophils using Helicobacter pylori as activator, by a luminol-amplified chemiluminescence assay. The extracts, at low concentration (5 g/mL), exhibited a large variation in inhibitory effects of H. pylori-induced oxidative burst ranging from 48% inhibition to inactive, but all extracts, excluding Byrsonima intermedia, had inhibitory activity over 80% at the concentration of 100 g/mL. The total suppressive antioxidant capacity measured as the effective concentration, which represents the extract concentration producing 50% inhibition of the chemiluminescence induced by H. pylori, varies from 27.2 to 56.8 g/mL and was in the following order: Qualea parviflora > Qualea multiflora > Alchornea triplinervia > Qualea grandiflora > Anacardium humile > Davilla elliptica > Mouriri pusa > Byrsonima basiloba > Alchornea glandulosa > Byrsonima intermedia. The main groups of compounds in tested extracts are presented. Differences in the phytochemical profile, quantitatively and qualitatively, of these plants can explain and justify their protective effect on the gastric mucosa caused by the neutrophil-generated ROS that occurs when H. pylori displays its evasion mechanisms. © 2013 Cibele Bonacorsi et al.en
dc.subjectAlchornea glandulosa extract-
dc.subjectAlchornea triplinervia extract-
dc.subjectAnacardium humile extract-
dc.subjectByrsonima basiloba extract-
dc.subjectByrsonima intermedia extract-
dc.subjectDavilla elliptica extract-
dc.subjectMouriri pusa extract-
dc.subjectplant extract-
dc.subjectQualea grandiflora extract-
dc.subjectQualea multiflora extract-
dc.subjectQualea parviflora extract-
dc.subjectunclassified drug-
dc.subjectAlchornea glandulosa-
dc.subjectAlchornea triplinervia-
dc.subjectAnacardium humile-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectantioxidant activity-
dc.subjectbacterium culture-
dc.subjectByrsonima basiloba-
dc.subjectByrsonima intermedia-
dc.subjectcell viability-
dc.subjectcontrolled study-
dc.subjectDavilla elliptica-
dc.subjectHelicobacter pylori-
dc.subjectmedicinal plant-
dc.subjectMouriri pusa-
dc.subjectperitoneum exudate-
dc.subjectpriority journal-
dc.subjectQualea grandiflora-
dc.subjectQualea multiflora-
dc.subjectQualea parviflora-
dc.subjectrespiratory burst-
dc.subjectstomach ulcer-
dc.titleComparison of Brazilian plants used to treat gastritis on the oxidative burst of helicobacter pylori -stimulated neutrophilen
dc.contributor.institutionUniversidade Federal de Mato Grosso-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)-
dc.description.affiliationInstituto de Ciências da Saúde Universidade Federal de Mato Grosso, 78557-267 Sinop, MT-
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, SP-
dc.description.affiliationDepartamento de Ciências Farmacêuticas Universidade Federal Do Espírito Santo, 29040-090 Vitória, ES-
dc.description.affiliationCampus Experimental Do Litoral Paulista Universidade Estadual Paulista (UNESP), 11330-900 São Vicente, SP-
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, SP-
dc.description.affiliationUnespCampus Experimental Do Litoral Paulista Universidade Estadual Paulista (UNESP), 11330-900 São Vicente, SP-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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