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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7633
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dc.contributor.authorCavicchioli, Mauricio-
dc.contributor.authorLeite, Clarice Q. F.-
dc.contributor.authorSato, Daisy N.-
dc.contributor.authorMassabni, Antonio Carlos-
dc.date.accessioned2014-05-20T13:24:31Z-
dc.date.accessioned2016-10-25T16:45:14Z-
dc.date.available2014-05-20T13:24:31Z-
dc.date.available2016-10-25T16:45:14Z-
dc.date.issued2007-10-01-
dc.identifierhttp://dx.doi.org/10.1002/ardp.200700040-
dc.identifier.citationArchiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 340, n. 10, p. 538-542, 2007.-
dc.identifier.issn0365-6233-
dc.identifier.urihttp://hdl.handle.net/11449/7633-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7633-
dc.description.abstractThe present work describes the synthesis and antimycobacterial activity of three Ag(I)-complexes with the sweeteners aspartame, saccharin, and cyclamate as ligands, with the aim of finding new candidate substances for fighting tuberculosis and other mycobacterial infections. The minimal inhibitory concentration of these three complexes was investigated in order to determine their in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium malmoense, and Mycobacterium kansasii. The MIC values were determined using the Microplate Alamar Blue Assay. The best MIC values found for the complexes were 9.75 mu M for Ag(l)-aspartame against M. kansasii and 15.7 mu M for Ag(I)-cyclamate against M. tuberculosis.en
dc.format.extent538-542-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectantimycobacterial activitypt
dc.subjectMABApt
dc.subjectsilver-aspartamept
dc.subjectsilver-cyclamatept
dc.subjectsilver-saccharinpt
dc.titleSynthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, Dept Ciências Biol, Araraquara, SP, Brazil-
dc.description.affiliationInst Adolfo Lutz Registro, Lab Ribeirao Preto, Ribeirao Preto, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, Dept Ciências Biol, Araraquara, SP, Brazil-
dc.identifier.doi10.1002/ardp.200700040-
dc.identifier.wosWOS:000250488600005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArchiv Der Pharmazie-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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