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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76404
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dc.contributor.authorOliveira, Gilberto Ornelas-
dc.contributor.authorBraga, Camila Pereira-
dc.contributor.authorFernandes, Ana Angelica Henrique-
dc.date.accessioned2014-05-27T11:30:32Z-
dc.date.accessioned2016-10-25T18:53:09Z-
dc.date.available2014-05-27T11:30:32Z-
dc.date.available2016-10-25T18:53:09Z-
dc.date.issued2013-09-01-
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2013.05.050-
dc.identifier.citationFood and Chemical Toxicology, v. 59, p. 256-260.-
dc.identifier.issn0278-6915-
dc.identifier.issn1873-6351-
dc.identifier.urihttp://hdl.handle.net/11449/76404-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76404-
dc.description.abstractThe aim of this study was to evaluate the effect of yacon (Smallanthus sonchifolius) (Poepp.& Endl.) on clinical parameters under diabetic conditions. The aqueous extract of yacon tuberous roots (YRAE; 0.76gfructankg-1 body weight) was prepared at the moment of each administration. Thirty-two male rats were divided into four groups (n=8): control group (C); group that received YRAE (Y); untreated diabetic group (DM1); and diabetic group treated with YRAE (Y-DM1). The diabetes mellitus was induced by streptozotocin (60mgkg-1 body weight). The animals from Y2 and Y-DM1 received YRAE by gavage, at 7-day intervals, for 30days. The aqueous extract of yacon roots decreased (p<0.05) the water and food intake in diabetic rats (Y-DM1). YRAE treatment reduced (p<0.05) glycaemia, total cholesterol, VLDL-c, LDL-c and triacylglycerol levels in diabetic rats (YRAE). HDL, urea and creatinine levels did not differ (p>0.05) between the Y and Y-DM1 groups. YRAE normalised alanine aminotransferase (ALT) activity, when comparing DM1 and Y-DM1 rats, but had no effect on lactate dehydrogenase activity (LDH). In conclusion, YRAE was sufficient for controlling water and food consumption, hyperglycaemia and dyslipidaemia, and promote the reduction of the ALT, suggesting a hepatoprotective effect in rats with STZ-induced DM1. © 2013 Elsevier Ltd.en
dc.format.extent256-260-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectDiabetes mellitus-
dc.subjectFructans-
dc.subjectMetabolism-
dc.subjectStreptozotocin-
dc.subjectYacon-
dc.subjectalanine aminotransferase-
dc.subjectcholesterol-
dc.subjectcreatinine-
dc.subjectglucose-
dc.subjecthigh density lipoprotein cholesterol-
dc.subjectlactate dehydrogenase-
dc.subjectplant extract-
dc.subjectSmallanthus sonchifolius extract-
dc.subjectstreptozocin-
dc.subjecttriacylglycerol-
dc.subjectunclassified drug-
dc.subjecturea-
dc.subjectvery low density lipoprotein cholesterol-
dc.subjectalanine aminotransferase blood level-
dc.subjectanimal experiment-
dc.subjectbody weight-
dc.subjectcholesterol blood level-
dc.subjectcontrolled study-
dc.subjectcreatinine blood level-
dc.subjectdrug efficacy-
dc.subjectdyslipidemia-
dc.subjectenzyme activity-
dc.subjectfluid intake-
dc.subjectfood intake-
dc.subjectgluconeogenesis-
dc.subjectglucose blood level-
dc.subjecthyperglycemia-
dc.subjectinsulin dependent diabetes mellitus-
dc.subjectlactate dehydrogenase blood level-
dc.subjectliver protection-
dc.subjectmale-
dc.subjectnonhuman-
dc.subjectplant root-
dc.subjectrat-
dc.subjectSmallanthus sonchifolius-
dc.subjectstreptozocin diabetes-
dc.subjecttriacylglycerol blood level-
dc.subjecturea blood level-
dc.titleImprovement of biochemical parameters in type 1 diabetic rats after the roots aqueous extract of yacon [Smallanthus sonchifolius (Poepp.& Endl.)] treatmenten
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInstituto de Biociências-
dc.description.affiliationDepartamento Clínica Médica Faculdade de Medicina de Botucatu-
dc.description.affiliationDepartamento de Química e Bioquímica Instituto de Biociências-
dc.description.affiliationDepartamento de Química e Bioquímica Instituto de Biociências Universidade Estadual Paulista, Campus de Botucatu, Rubião Júnior, Botucatu, São Paulo 18618-970-
dc.description.affiliationUnespDepartamento Clínica Médica Faculdade de Medicina de Botucatu-
dc.description.affiliationUnespDepartamento de Química e Bioquímica Instituto de Biociências Universidade Estadual Paulista, Campus de Botucatu, Rubião Júnior, Botucatu, São Paulo 18618-970-
dc.identifier.doi10.1016/j.fct.2013.05.050-
dc.identifier.wosWOS:000324280000033-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84880091627.pdf-
dc.relation.ispartofFood and Chemical Toxicology-
dc.identifier.scopus2-s2.0-84880091627-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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