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dc.contributor.authorRafacho, A.-
dc.contributor.authorGonçalves-Neto, L. M.-
dc.contributor.authorFerreira, F. B D-
dc.contributor.authorProtzek, A. O P-
dc.contributor.authorBoschero, A. C.-
dc.contributor.authorNunes, E. A.-
dc.contributor.authorZoccal, Daniel Breseghello-
dc.identifier.citationActa Physiologica, v. 209, n. 1, p. 77-89, 2013.-
dc.description.abstractAim: Chronic exposure to intermittent hypoxia commonly induces the activation of sympathetic tonus and the disruption of glucose homoeostasis. However, the effects of exposure to acute intermittent hypoxia (AIH) on glucose homoeostasis are not yet fully elucidated. Herein, we evaluated parameters related to glucose metabolism in rats exposed to AIH. Methods: Male adult rats were submitted to 10 episodes of hypoxia (6% O2, for 45 s) interspersed with 5-min intervals of normoxia (21%), while the control (CTL) group was kept in normoxia. Results: Acute intermittent hypoxia rats presented higher fasting glycaemia, normal insulinaemia, increased lactataemia and similar serum lipid levels, compared to controls (n = 10, P < 0.05). Additionally, AIH rats exhibited increased glucose tolerance (GT) (n = 10, P < 0.05) and augmented insulin sensitivity (IS) (n = 10, P < 0.05). The p-Akt/Akt protein ratio was increased in the muscle, but not in the liver and adipose tissue of AIH rats (n = 6, P < 0.05). The elevated glycaemia in AIH rats was associated with a reduction in the hepatic glycogen content (n = 10, P < 0.05). Moreover, the AIH-induced increase in blood glucose concentration, as well as reduced hepatic glycogen content, was prevented by prior systemic administration of the β-adrenergic antagonist (P < 0.05). The effects of AIH on glycaemia and Akt phosphorylation were transient and not observed after 60 min. Conclusions: We suggest that AIH induces an increase in blood glucose concentration as a result of hepatic glycogenolysis recruitment through sympathetic activation. The augmentation of GT and IS might be attributed, at least in part, to increased β-adrenergic sympathetic stimulation and Akt protein activation in skeletal muscles, leading to a higher glucose availability and utilization. © 2013 Scandinavian Physiological Society.en
dc.subjectBlood glucose-
dc.subjectGlucose tolerance-
dc.subjectInsulin sensitivity-
dc.subjectIntermittent hypoxia-
dc.subjectSympathetic activity-
dc.subjectlactic acid-
dc.subjectprotein kinase B-
dc.subjectadipose tissue-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectcontrolled study-
dc.subjectglucose blood level-
dc.subjectglucose homeostasis-
dc.subjectglucose metabolism-
dc.subjectglucose tolerance-
dc.subjectglycogen liver level-
dc.subjectheart rate-
dc.subjectinsulin blood level-
dc.subjectinsulin sensitivity-
dc.subjectintermittent hypoxia-
dc.subjectlactate blood level-
dc.subjectlipid blood level-
dc.subjectmean arterial pressure-
dc.subjectmetabolic parameters-
dc.subjectpriority journal-
dc.subjectprotein phosphorylation-
dc.subjectskeletal muscle-
dc.subjectsympathetic function-
dc.titleGlucose homoeostasis in rats exposed to acute intermittent hypoxiaen
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Physiological Sciences Centre of Biological Sciences UFSC - Federal University of de Santa Catarina, Florianópolis, Santa Catarina-
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biology UNICAMP - State University of Campinas, Campinas, São Paulo-
dc.description.affiliationDepartment of Physiology and Pathology Dentistry School of Araraquara São Paulo State University, UNESP, Araraquara-
dc.description.affiliationUnespDepartment of Physiology and Pathology Dentistry School of Araraquara São Paulo State University, UNESP, Araraquara-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofActa Physiologica-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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