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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76440
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dc.contributor.authorDa Rosa, L. C.-
dc.contributor.authorChiuso-Minicucci, F.-
dc.contributor.authorZorzella-Pezavento, S. F G-
dc.contributor.authorFrança, T. G D-
dc.contributor.authorIshikawa, L. L W-
dc.contributor.authorColavite, P. M.-
dc.contributor.authorBalbino, B.-
dc.contributor.authorTavares, L. C B-
dc.contributor.authorSilva, C. L.-
dc.contributor.authorMarques, C.-
dc.contributor.authorIkoma, M. R V-
dc.contributor.authorSartori, A.-
dc.date.accessioned2014-05-27T11:30:33Z-
dc.date.accessioned2016-10-25T18:53:35Z-
dc.date.available2014-05-27T11:30:33Z-
dc.date.available2016-10-25T18:53:35Z-
dc.date.issued2013-09-01-
dc.identifierhttp://dx.doi.org/10.1111/cei.12140-
dc.identifier.citationClinical and Experimental Immunology, v. 173, n. 3, p. 430-437, 2013.-
dc.identifier.issn0009-9104-
dc.identifier.issn1365-2249-
dc.identifier.urihttp://hdl.handle.net/11449/76440-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76440-
dc.description.abstractType I diabetes is a disease caused by autoimmune destruction of the beta cells in the pancreas that leads to a deficiency in insulin production. The aim of this study was to evaluate the prophylactic potential of a prime-boost strategy involving bacille Calmette-Guérin (BCG) and the pVAXhsp65 vaccine (BCG/DNAhsp65) in diabetes induced by streptozotocin (STZ) in C57BL/6 mice and also in spontaneous type 1 diabetes in non-obese diabetic (NOD) mice. BCG/DNAhsp65 vaccination in NOD mice determined weight gain, protection against hyperglycaemia, decreased islet inflammation, higher levels of cytokine production by the spleen and a reduced number of regulatory T cells in the spleen compared with non-immunized NOD mice. In the STZ model, however, there was no significant difference in the clinical parameters. Although this vaccination strategy did not protect mice in the STZ model, it was very effective in NOD mice. This is the first report demonstrating that a prime-boost strategy could be explored as an immunomodulatory procedure in autoimmune diseases. © 2013 British Society for Immunology.en
dc.format.extent430-437-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectBCG-
dc.subjectHsp65-
dc.subjectImmunomodulation-
dc.subjectNOD mice-
dc.subjectType 1 diabetes-
dc.subjectBCG vaccine-
dc.subjectDNA vaccine-
dc.subjectpVAXhsp65 vaccine-
dc.subjectstreptozocin-
dc.subjectunclassified drug-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectBCG vaccination-
dc.subjectcontrolled study-
dc.subjectcytokine production-
dc.subjectfemale-
dc.subjecthyperglycemia-
dc.subjectimmunomodulation-
dc.subjectinsulin dependent diabetes mellitus-
dc.subjectmale-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectregulatory T lymphocyte-
dc.subjectspleen-
dc.subjectweight gain-
dc.titleBacille Calmette-Guérin/DNAhsp65 prime-boost is protective against diabetes in non-obese diabetic mice but not in the streptozotocin model of type 1 diabetesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionLaboratório de Citometria de Fluxo-
dc.description.affiliationDepartment of Microbiology and Immunology Biosciences Institute Universidade Estadual Paulista (UNESP), Botucatu-
dc.description.affiliationDepartment of Biochemistry and Immunology University of São Paulo (USP), Ribeirão Preto-
dc.description.affiliationFundação Dr Amaral Carvalho Laboratório de Citometria de Fluxo, Jaú, São Paulo-
dc.description.affiliationUnespDepartment of Microbiology and Immunology Biosciences Institute Universidade Estadual Paulista (UNESP), Botucatu-
dc.identifier.doi10.1111/cei.12140-
dc.identifier.wosWOS:000322774800006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofClinical and Experimental Immunology-
dc.identifier.scopus2-s2.0-84881512633-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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