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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76618
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dc.contributor.authorBachiega, T. F.-
dc.contributor.authorDe Sousa, J. P B-
dc.contributor.authorBastos, J. K.-
dc.contributor.authorSforcin, J. M.-
dc.date.accessioned2014-05-27T11:30:43Z-
dc.date.accessioned2016-10-25T18:54:16Z-
dc.date.available2014-05-27T11:30:43Z-
dc.date.available2016-10-25T18:54:16Z-
dc.date.issued2013-09-23-
dc.identifierhttp://dx.doi.org/10.1080/14786419.2012.742078-
dc.identifier.citationNatural Product Research, v. 27, n. 18, p. 1646-1650, 2013.-
dc.identifier.issn1478-6419-
dc.identifier.issn1478-6427-
dc.identifier.urihttp://hdl.handle.net/11449/76618-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76618-
dc.description.abstractA possible immunomodulatory/anti-inflammatory effect of Baccharis dracunculifolia (Bd) and its major compound - caffeic acid (Ca) - on cytokines production (IL-1b, IL-6 and IL-10) by murine macrophages was investigated. Cells were incubated with Bd and Ca, and the inhibitory concentrations were tested before or after macrophages challenge with LPS. Bd and Ca stimulated IL-1b and inhibited IL-6 and IL-10 production. In LPS-challenge protocols, Bd prevented LPS action either before or after LPS challenge, whereas Ca prevented LPS effects only after LPS addition. Bd modulatory action on cytokines production may be at least in part mediated by Ca, since it has been shown to inhibit the transcription factor NF-kB. Further studies are still needed to evaluate Bd efficacy in inflammatory diseases, in order to explore its antiinflammatory activity in vivo. © 2013 Taylor & Francis.en
dc.format.extent1646-1650-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectBaccharis dracunculifolia-
dc.subjectCaffeic acid-
dc.subjectCytokines-
dc.subjectImmunomodulation-
dc.subject2,2 dimethyl 6 carboxyethenyl 2h 1 benzopyran acid-
dc.subjectantiinflammatory agent-
dc.subjectartepilin C-
dc.subjectBaccharis dracunculifolia extract-
dc.subjectcaffeic acid-
dc.subjectdexamethasone-
dc.subjectferulic acid-
dc.subjectimmunoglobulin enhancer binding protein-
dc.subjectimmunomodulating agent-
dc.subjectinterleukin 10-
dc.subjectinterleukin 1beta-
dc.subjectinterleukin 6-
dc.subjectisosakuranetin-
dc.subjectlipopolysaccharide-
dc.subjectplant extract-
dc.subjectunclassified drug-
dc.subjectveratraldehyde-
dc.subjectanimal cell-
dc.subjectantiinflammatory activity-
dc.subjectcontrolled study-
dc.subjectcytokine production-
dc.subjectdrug mechanism-
dc.subjectimmunomodulation-
dc.subjectin vitro study-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectperitoneum macrophage-
dc.subjectplant leaf-
dc.subjectprovocation test-
dc.titleImmunomodulatory/anti-inflammatory effects of Baccharis dracunculifolia leavesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationDepartment of Microbiology and Immunology Biosciences Institute, UNESP, Botucatu, SP 18618-970-
dc.description.affiliationDepartment of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeirão Preto USP, Ribeirão Preto, SP 14040-903-
dc.description.affiliationUnespDepartment of Microbiology and Immunology Biosciences Institute, UNESP, Botucatu, SP 18618-970-
dc.identifier.doi10.1080/14786419.2012.742078-
dc.identifier.wosWOS:000324087900006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofNatural Product Research-
dc.identifier.scopus2-s2.0-84884250067-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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