You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76651
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBatista-Duharte, Alexander-
dc.contributor.authorPortuondo, Deivys-
dc.contributor.authorCarlos, Iracilda Zeppone-
dc.contributor.authorPérez, Oliver-
dc.date.accessioned2014-05-27T11:30:45Z-
dc.date.accessioned2016-10-25T18:54:29Z-
dc.date.available2014-05-27T11:30:45Z-
dc.date.available2016-10-25T18:54:29Z-
dc.date.issued2013-09-27-
dc.identifierhttp://dx.doi.org/10.1016/j.intimp.2013.07.025-
dc.identifier.citationInternational Immunopharmacology, v. 17, n. 3, p. 526-536, 2013.-
dc.identifier.issn1567-5769-
dc.identifier.issn1878-1705-
dc.identifier.urihttp://hdl.handle.net/11449/76651-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76651-
dc.description.abstractThe occurrence of injection site reactions following immunization is the most frequently reported toxicity manifestation of vaccines; however, the different types of local reactions and the different mechanisms involved are still unclear. Here, the current advances in adjuvants and the role that adjuvants play in local reactions are reviewed. The role of adjuvants in the formation of the loco-regional complex (LRC), which consists of the injection site, draining lymphatic vessels and regional lymph nodes, is also discussed. Finally, strategies and recommendations for the rational design of adjuvanted vaccines are discussed, with a particular interest in the reduction of local inflammation. © 2013 Elsevier B.V.en
dc.format.extent526-536-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAction mechanism-
dc.subjectAdjuvant-
dc.subjectImmunotoxicity-
dc.subjectLocal reaction-
dc.subjectVaccine-
dc.subjectBCG vaccine-
dc.subjectpoliomyelitis vaccine-
dc.subjectvaccine-
dc.subjectadaptive immunity-
dc.subjectantigen presenting cell-
dc.subjectArthus phenomenon-
dc.subjectBCG vaccination-
dc.subjectcarcinogenesis-
dc.subjectdelayed hypersensitivity-
dc.subjectdrug induced disease-
dc.subjectgranuloma-
dc.subjecthuman-
dc.subjectimmunization-
dc.subjectimmunotoxicity-
dc.subjectinjection site nodule-
dc.subjectinnate immunity-
dc.subjectlymphadenitis-
dc.subjectlymphatic drainage-
dc.subjectlymphoid hyperplasia-
dc.subjectPersian Gulf syndrome-
dc.subjectpriority journal-
dc.subjectpseudolymphoma-
dc.subjectsubcutaneous nodule-
dc.subjecttuberculosis-
dc.subjecturticaria-
dc.titleAn approach to local immunotoxicity induced by adjuvanted vaccinesen
dc.typeoutro-
dc.contributor.institutionMedical Science University-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionFinlay Institute-
dc.description.affiliationImmunotoxicology Laboratory Toxicology and Biomedicine Center (TOXIMED) Medical Science University, Autopista Nacional Km. 1, CP 90400 Santiago de Cuba-
dc.description.affiliationFaculty of Pharmaceutical Sciences Universidade Estadual Paulista Julio Mesquita Filho UNESP, Rua Expedicionarios do Brasil 1621-CEP:14801-902, Araraquara, SP-
dc.description.affiliationDepartment of Immunology Research and Development Vice-presidency Finlay Institute, Ave 27 No. 19805, Havana-
dc.description.affiliationUnespFaculty of Pharmaceutical Sciences Universidade Estadual Paulista Julio Mesquita Filho UNESP, Rua Expedicionarios do Brasil 1621-CEP:14801-902, Araraquara, SP-
dc.identifier.doi10.1016/j.intimp.2013.07.025-
dc.identifier.wosWOS:000327280100007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInternational Immunopharmacology-
dc.identifier.scopus2-s2.0-84884519475-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
Show simple item record Show full item record   View Statistics
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.