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dc.contributor.authorTjäderhane, Leo-
dc.contributor.authorMehtälä, Pekka-
dc.contributor.authorScaffa, Polliana-
dc.contributor.authorVidal, Cristina-
dc.contributor.authorPääkkönen, Virve-
dc.contributor.authorBreschi, Lorenzo-
dc.contributor.authorHebling, Josimeri-
dc.contributor.authorTay, Franklin R.-
dc.contributor.authorNascimento, Fabio D.-
dc.contributor.authorPashley, David H.-
dc.contributor.authorCarrilho, Marcela R.-
dc.identifier.citationDental Materials, v. 29, n. 10, p. 1055-1062, 2013.-
dc.description.abstractObjective The objective was to examine the effect of a solvent dimethyl sulfoxide (DMSO) on resin-dentin bond durability, as well as potential functional mechanisms behind the effect. Methods Microtensile bond strength (μTBS) was evaluated in extracted human teeth in two separate experiments. Dentin specimens were acid-etched and assigned to pre-treatment with 0.5 mM (0.004%) DMSO as additional primer for 30 s and to controls with water pre-treatment. Two-step etch-and-rinse adhesive (Scotchbond 1XT, 3M ESPE) was applied and resin composite build-ups were created. Specimens were immediately tested for μTBS or stored in artificial saliva for 6 and 12 months prior to testing. Additional immediate and 6-month specimens were examined for interfacial nanoleakage analysis under SEM. Matrix metalloproteinase (MMP) inhibition by DMSO was examined with gelatin zymography. Demineralized dentin disks were incubated in 100% DMSO to observe the optical clearing effect. Results The use of 0.5 mM DMSO had no effect on immediate bond strength or nanoleakage. In controls, μTBS decreased significantly after storage, but increased significantly in DMSO-treated group. The control group had significantly lower μTBS than DMSO-group after 6 and 12 months. DMSO also eliminated the increase in nanoleakage seen in controls. 5% and higher DMSO concentrations significantly inhibited the gelatinases. DMSO induced optical clearing effect demonstrating collagen dissociation. Significance DMSO as a solvent may be useful in improving the preservation of long-term dentin-adhesive bond strength. The effect may relate to dentinal enzyme inhibition or improved wetting of collagen by adhesives. The collagen dissociation required much higher DMSO concentrations than the 0.5 mM DMSO used for bonding. © 2013 Academy of Dental Materials.en
dc.subjectDentin bonding-
dc.subjectMatrix metalloproteinase-
dc.subjectMatrix metalloproteinases-
dc.subjectBond (masonry)-
dc.subjectBond strength (materials)-
dc.subjectDimethyl sulfoxide-
dc.subjectEnzyme inhibition-
dc.subjectWater treatment-
dc.subjectOrganic solvents-
dc.titleThe effect of dimethyl sulfoxide (DMSO) on dentin bonding and nanoleakage of etch-and-rinse adhesivesen
dc.contributor.institutionOulu University Hospital-
dc.contributor.institutionUniversity of Turku-
dc.contributor.institutionNordic Institute of Dental Materials (NIOM)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversity of Trieste-
dc.contributor.institutionC/o IOR-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionMedical College of Georgia-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversity of Western Ontario-
dc.description.affiliationInstitute of Dentistry University of Oulu Oulu University Hospital, PO Box 5281, 90014 Oulu-
dc.description.affiliationInstitute of Dentistry University of Turku, Turku-
dc.description.affiliationNordic Institute of Dental Materials (NIOM), Oslo-
dc.description.affiliationEstate University of Campinas Piracicaba Dental School (FOP/UNICAMP), São Paulo-
dc.description.affiliationDepartment of Biomedicine Unit of Dental Sciences and Biomaterials University of Trieste, Trieste-
dc.description.affiliationIGM-CNR Unit of Bologna C/o IOR, Bologna-
dc.description.affiliationDepartment of Orthodontics and Pediatric Dentistry Araraquara School of Dentistry São Paulo State University UNESP, Araraquara, SP-
dc.description.affiliationDepartment of Oral Biology and Maxillofacial Pathology School of Dentistry Medical College of Georgia, Augusta, GA-
dc.description.affiliationBandeirante University of São Paulo (UNIBAN), São Paulo-
dc.description.affiliationSchulich Dentistry University of Western Ontario, London, ON-
dc.description.affiliationUnespDepartment of Orthodontics and Pediatric Dentistry Araraquara School of Dentistry São Paulo State University UNESP, Araraquara, SP-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofDental Materials-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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