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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76768
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dc.contributor.authorDe Freitas Araújo, Marcelo Gonzaga-
dc.contributor.authorPacífico, Mariana-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorDos Santos, Lourdes Campaner-
dc.contributor.authorIcely, Paula Alejandra-
dc.contributor.authorMiró, Maria Soledad-
dc.contributor.authorScarpa, Maria Virginia Costa-
dc.contributor.authorBauab, Taís Maria-
dc.contributor.authorSotomayor, Claudia Elena-
dc.date.accessioned2014-05-27T11:30:49Z-
dc.date.accessioned2016-10-25T18:54:48Z-
dc.date.available2014-05-27T11:30:49Z-
dc.date.available2016-10-25T18:54:48Z-
dc.date.issued2013-10-01-
dc.identifierhttp://dx.doi.org/10.3109/13693786.2013.795294-
dc.identifier.citationMedical Mycology, v. 51, n. 7, p. 673-682, 2013.-
dc.identifier.issn1369-3786-
dc.identifier.issn1460-2709-
dc.identifier.urihttp://hdl.handle.net/11449/76768-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/76768-
dc.description.abstractThe purpose of this study was to evaluate the in vitro anticandidal activity of a methanolic extract of Syngonanthus nitens scapes against different Candida species and clinical isolates from patients with vulvovaginal candidiasis (VVC), and its effect in vivo in the treatment of vaginal infection. Chemical characterization of the extract was performed by HPLC-UV analyses and showed the presence of flavones derivatives. The extract was effective against several Candida strains from our collection and species recovered from VVC patients, and was able to inhibit the yeast-hyphal transition. No cytotoxic activity against human female reproductive tract epithelial cells and no hemolytic activity against human red blood cells were observed. In the in vivo model of VVC, we evaluated the efficacy of the intravaginal treatment with a cream containing the extract at doses of 0.5, 1.0 and 2.0%. The treatment eradicated the vaginal fungal burden in infected rats after 8 days of treatment. S. nitens extract could be considered as an effective and non-toxic natural antifungal agent in the treatment of vulvovaginal candidiasis. © 2013 ISHAM.en
dc.format.extent673-682-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAnticandidal activity-
dc.subjectSyngonanthus nitens-
dc.subjectVulvovaginal candidiasis-
dc.subjectYeast-hyphal transition-
dc.subjectamphotericin B-
dc.subjectantifungal agent-
dc.subjectflavone derivative-
dc.subjectflavonoid-
dc.subjectplant extract-
dc.subjectSyngonanthus nitens extract-
dc.subjectunclassified drug-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectantifungal activity-
dc.subjectantifungal susceptibility-
dc.subjectCandida albicans-
dc.subjectCandida krusei-
dc.subjectCandida parapsilosis-
dc.subjectCandida tropicalis-
dc.subjectcell damage-
dc.subjectcontrolled study-
dc.subjectcream-
dc.subjectdrug cytotoxicity-
dc.subjectdrug efficacy-
dc.subjectepithelium cell-
dc.subjectEriocaulaceae-
dc.subjecterythrocyte-
dc.subjectevaluation-
dc.subjectfemale-
dc.subjectfemale genital system-
dc.subjectfungus growth-
dc.subjectgrowth inhibition-
dc.subjecthemolysis-
dc.subjecthigh performance liquid chromatography-
dc.subjecthuman-
dc.subjecthuman cell-
dc.subjectin vitro study-
dc.subjectminimum inhibitory concentration-
dc.subjectnonhuman-
dc.subjectrat-
dc.subjectultraviolet spectroscopy-
dc.subjectvagina candidiasis-
dc.subjectvaginitis-
dc.titleEvaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasisen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionChemistry Institute-
dc.contributor.institutionNational University of Cordoba-
dc.description.affiliationBiological Sciences Department Faculty of Pharmaceutical Sciences São Paulo State University (UNESP), Araraquara, SP-
dc.description.affiliationOrganic Chemistry Department Chemistry Institute, Araraquara, SP-
dc.description.affiliationDrugs and Pharmaceuticals Department Faculty of Pharmaceutical Sciences São Paulo State University-UNESP, Araraquara, SP-
dc.description.affiliationClinical Biochemistry Department Immunology, CIBICI-CONICET National University of Cordoba, Cordoba-
dc.description.affiliationUnespBiological Sciences Department Faculty of Pharmaceutical Sciences São Paulo State University (UNESP), Araraquara, SP-
dc.description.affiliationUnespDrugs and Pharmaceuticals Department Faculty of Pharmaceutical Sciences São Paulo State University-UNESP, Araraquara, SP-
dc.identifier.doi10.3109/13693786.2013.795294-
dc.identifier.wosWOS:000324538900001-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMedical Mycology-
dc.identifier.scopus2-s2.0-84884330991-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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