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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7709
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dc.contributor.authorChung, M. C.-
dc.contributor.authorGuido, RVC-
dc.contributor.authorMartinelli, T. F.-
dc.contributor.authorGoncalves, M. F.-
dc.contributor.authorPolli, M. C.-
dc.contributor.authorBotelho, KCA-
dc.contributor.authorVaranda, Eliana Aparecida-
dc.contributor.authorColli, W.-
dc.contributor.authorMiranda, MTM-
dc.contributor.authorFerreira, E. I.-
dc.date.accessioned2014-05-20T13:24:38Z-
dc.date.accessioned2016-10-25T16:45:22Z-
dc.date.available2014-05-20T13:24:38Z-
dc.date.available2016-10-25T16:45:22Z-
dc.date.issued2003-11-03-
dc.identifierhttp://dx.doi.org/10.1016/j.bmc.2003.07.004-
dc.identifier.citationBioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V., v. 11, n. 22, p. 4779-4783, 2003.-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://hdl.handle.net/11449/7709-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7709-
dc.description.abstractThe synthesis of mutual prodrugs of nitrofurazone with primaquine, using specific and nonspecific spacer groups, has been previously attempted seeking selective antichagasic agents. The intermediate reaction product, hydroxymethylnitrofurazone (NFOH-121), was isolated and tested in LLC-MK2 culture cells infected with trypomastigotes forms of Trypanosoma cruzi showing higher trypanocidal activity than nitrofurazone and benznidazol in all stages. The mutagenicity tests showed that the prodrug was less toxic than the parent drug. Degradation assays were carried out in pH 1.2 and 7.4. (C) 2003 Elsevier Ltd. All rights reserved.en
dc.format.extent4779-4783-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.titleSynthesis and in vitro evaluation of potential antichagasic hydroxymethyinitrofurazone (NFOH-121): A new nitrofurazone prodrugen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUSP, Dept Farm, Fac Ciências Farmaceut, BR-05389970 São Paulo, Brazil-
dc.description.affiliationUNESP, Lapdesf Lab Pesquisa & Desenvolvimento Farm, Dept Farmacos & Med, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUNESP, Dept Ciências Biol, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Lapdesf Lab Pesquisa & Desenvolvimento Farm, Dept Farmacos & Med, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Ciências Biol, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.doi10.1016/j.bmc.2003.07.004-
dc.identifier.wosWOS:000186134200010-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBioorganic & Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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