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http://acervodigital.unesp.br/handle/11449/7753
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DC Field | Value | Language |
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dc.contributor.author | Cardillo, Jose A. | - |
dc.contributor.author | Paganelli, Fernando | - |
dc.contributor.author | Melo, Luiz A. S. | - |
dc.contributor.author | Silva, Arnobio A. | - |
dc.contributor.author | Pizzolitto, Antonio Carlos | - |
dc.contributor.author | Oliveira, Anselmo Gomes de | - |
dc.date.accessioned | 2014-05-20T13:24:43Z | - |
dc.date.accessioned | 2016-10-25T16:45:26Z | - |
dc.date.available | 2014-05-20T13:24:43Z | - |
dc.date.available | 2016-10-25T16:45:26Z | - |
dc.date.issued | 2010-01-01 | - |
dc.identifier | http://dx.doi.org/10.1001/archophthalmol.2009.352 | - |
dc.identifier.citation | Archives of Ophthalmology. Chicago: Amer Medical Assoc, v. 128, n. 1, p. 81-87, 2010. | - |
dc.identifier.issn | 0003-9950 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7753 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/7753 | - |
dc.description.abstract | Objective: To compare the efficacy of subconjunctival injection of a combination of triamcinolone and ciprofloxacin hydrochloride, 2 mg/0.1 mL, in a controlled-release system (DuoCat) with that of ciprofloxacin hydrochloride, 0.3%, eyedrops for infection prophylaxis.Methods: Rabbit eyes were injected subconjunctivally with a combination of triamcinolone and ciprofloxacin hydrochloride, 2mg/0.1 mL, or ciprofloxacin hydrochloride, 2 mg/0.1 mL, alone. The aqueous and vitreous humor pharmacokinetic profiles were compared with those of a single drop of ciprofloxacin hydrochloride, 0.3%, 6 times daily. In 45 rabbits, Staphylococcus aureus was injected into the anterior chamber: 15 randomly received 1 drop of ciprofloxacin hydrochloride, 0.3%, every 4 hours during 24 hours; 15 received drops of balanced salt solution; and 15 received a combination of triamcinolone and ciprofloxacin hydrochloride, 2 mg/0.1 mL. After 24 hours, endophthalmitis scores were recorded, aqueous and vitreous humors underwent culture, and histologic analysis was performed.Results: The combined triamcinolone and ciprofloxacin treatment allowed higher intraocular levels of ciprofloxacin. The median endophthalmitis clinical scores for the combination of triamcinolone and ciprofloxacin and ciprofloxacin-only eyedrop groups were equivalent (P=.42) and were significantly lower than those of the balanced salt solution group (P<.001). The culture was negative for S aureus in the combined triamcinolone and ciprofloxacin and ciprofloxacin eyedrop regimens. No adverse effects were observed with either route.Conclusions: Ciprofloxacin eyedrops and combined triamcinolone and ciprofloxacin were equally tolerated and efficacious. The combined triamcinolone and ciprofloxacin treatment may eliminate noncompliance issues and may prove to be a valuable clinical tool for surgical prophylaxis.Clinical Relevance: The combined triamcinolone and ciprofloxacin treatment may be a new useful strategy for surgical prophylaxis. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 81-87 | - |
dc.language.iso | eng | - |
dc.publisher | Amer Medical Assoc | - |
dc.source | Web of Science | - |
dc.title | Subconjunctival Delivery of Antibiotics in a Controlled-Release System A Novel Anti-infective Prophylaxis Approach for Cataract Surgery | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Hosp Olhos Araraquara | - |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | - |
dc.contributor.institution | UNIARA | - |
dc.description.affiliation | Univ Estadual Paulista, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil | - |
dc.description.affiliation | Hosp Olhos Araraquara, São Paulo, Brazil | - |
dc.description.affiliation | Univ Fed São Paulo, EPM, Dept Ophthalmol, São Paulo, Brazil | - |
dc.description.affiliation | UNIARA, São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil | - |
dc.description.sponsorshipId | FAPESP: 98/10066-7 | - |
dc.description.sponsorshipId | CNPq: 473105/2007-1 | - |
dc.description.sponsorshipId | CNPq: 301809/2007-0 | - |
dc.identifier.doi | 10.1001/archophthalmol.2009.352 | - |
dc.identifier.wos | WOS:000273532800011 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.relation.ispartof | Archives of Ophthalmology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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