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http://acervodigital.unesp.br/handle/11449/7781Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chin, Chung Man | - |
| dc.contributor.author | dos Santos, Jean Leandro | - |
| dc.contributor.author | Oliveira, Ednir Vizioli | - |
| dc.contributor.author | Blau, Lorena | - |
| dc.contributor.author | Menegon, Renato Farina | - |
| dc.contributor.author | Peccinini, Rosangela Goncalves | - |
| dc.date.accessioned | 2014-05-20T13:24:46Z | - |
| dc.date.available | 2014-05-20T13:24:46Z | - |
| dc.date.issued | 2009-09-01 | - |
| dc.identifier | http://dx.doi.org/10.3390/molecules14093187 | - |
| dc.identifier.citation | Molecules. Basel: Molecular Diversity Preservation International-mdpi, v. 14, n. 9, p. 3187-3197, 2009. | - |
| dc.identifier.issn | 1420-3049 | - |
| dc.identifier.uri | http://hdl.handle.net/11449/7781 | - |
| dc.description.abstract | The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 showed anti-inflammatory and analgesic activity without gastro-ulcerogenic effects. The chemical and enzymatic hydrolysis profile of the lactam derivative 1 does not indicate conversion to diclofenac (2). This compound is a new non-ulcerogenic prototype for treatment of chronic inflammatory diseases. | en |
| dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
| dc.format.extent | 3187-3197 | - |
| dc.language.iso | eng | - |
| dc.publisher | Molecular Diversity Preservation International-mdpi | - |
| dc.source | Web of Science | - |
| dc.subject | indolinone | en |
| dc.subject | pro-drug | en |
| dc.subject | anti-inflammatory | en |
| dc.subject | hydrolysis | en |
| dc.subject | diclofenac | en |
| dc.title | Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties | en |
| dc.type | outro | - |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
| dc.description.affiliation | UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, BR-14801902 Araraquara, SP, Brazil | - |
| dc.description.affiliation | UNESP, Fac Ciencias Farmaceut, Dept Principios Ativos Nat & Toxicol, BR-14801902 Araraquara, SP, Brazil | - |
| dc.description.affiliationUnesp | UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, BR-14801902 Araraquara, SP, Brazil | - |
| dc.description.affiliationUnesp | UNESP, Fac Ciencias Farmaceut, Dept Principios Ativos Nat & Toxicol, BR-14801902 Araraquara, SP, Brazil | - |
| dc.description.sponsorshipId | FAPESP: 07/56115-0 | - |
| dc.identifier.doi | 10.3390/molecules14093187 | - |
| dc.identifier.wos | WOS:000270201900007 | - |
| dc.rights.accessRights | Acesso aberto | - |
| dc.identifier.file | WOS000270201900007.pdf | - |
| dc.relation.ispartof | Molecules | - |
| Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp | |
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