You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7790
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLopes, Cristiani C. G. O.-
dc.contributor.authorSalgado, Hérida Regina Nunes-
dc.date.accessioned2014-05-20T13:24:47Z-
dc.date.accessioned2016-10-25T16:45:27Z-
dc.date.available2014-05-20T13:24:47Z-
dc.date.available2016-10-25T16:45:27Z-
dc.date.issued2009-06-01-
dc.identifierhttp://dx.doi.org/10.1365/s10337-009-0993-3-
dc.identifier.citationChromatographia. Wiesbaden: Vieweg, v. 69, p. 129-135, 2009.-
dc.identifier.issn0009-5893-
dc.identifier.urihttp://hdl.handle.net/11449/7790-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7790-
dc.description.abstractThis paper describes the validation of an isocratic LC method for the assay of linezolid in tablets. Validation parameters such as linearity, precision, accuracy, specificity, limit of detection, limit of quantitation and robustness were determined. LC was carried out by reversed phase technique on an RP-18 column with a mobile phase composed of 1% acetic acid:methanol:acetonitrile (50:25:25, v/v/v). Linezolid and your combination drug product were exposed to acid, base, oxidation, dry heat and photolytic stress conditions. A linear response (r > 0.9999) was observed in the range of 8.0-20.0 mu g mL(-1). The retention time of linezolid was 4.6 min. The method showed good recoveries and intra- and inter-day relative standard deviations were less than 1.0%. The LOD and LOQ were 0.21 and 0.63 mu g mL(-1), respectively. The developed LC method for determination of related substances and assay determination of linezolid can be used to evaluate the quality of regular production samples. It can also be used to test the stability samples of linezolid.en
dc.description.sponsorshipPACD-FCFAr-UNESP (Araraquara, Brazil)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipFUND-UNESP (São Paulo, Brazil)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent129-135-
dc.language.isoeng-
dc.publisherVieweg-
dc.sourceWeb of Science-
dc.subjectColumn liquid chromatographyen
dc.subjectValidationen
dc.subjectLinezoliden
dc.titleDevelopment of a Validated Stability-Indicating LC Assay and Stress Degradation Studies of Linezolid in Tabletsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.doi10.1365/s10337-009-0993-3-
dc.identifier.wosWOS:000267330400005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofChromatographia-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.