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dc.contributor.authorFormariz, T. P.-
dc.contributor.authorChiavacci, Leila Aparecida-
dc.contributor.authorScarpa, M. V.-
dc.contributor.authorSilva-Junior, A. A.-
dc.contributor.authorEgito, E. S. T.-
dc.contributor.authorTerrugi, C. H. B.-
dc.contributor.authorFranzini, C. M.-
dc.contributor.authorSarmento, V. H. V.-
dc.contributor.authorOliveira, Anselmo Gomes de-
dc.date.accessioned2014-05-20T13:24:48Z-
dc.date.accessioned2016-10-25T16:45:28Z-
dc.date.available2014-05-20T13:24:48Z-
dc.date.available2016-10-25T16:45:28Z-
dc.date.issued2010-05-01-
dc.identifierhttp://dx.doi.org/10.1016/j.colsurfb.2010.01.004-
dc.identifier.citationColloids and Surfaces B-biointerfaces. Amsterdam: Elsevier B.V., v. 77, n. 1, p. 47-53, 2010.-
dc.identifier.issn0927-7765-
dc.identifier.urihttp://hdl.handle.net/11449/7795-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7795-
dc.description.abstractStructure and viscoelastic properties of negatively charged oil-in-water (o/w) microemulsions have been investigated. Microemulsions (ME) containing soya phosphatidylcholine (SPC), eumulgin HRE 40 ( EU) and sodium oleate (SO) as surfactant, cholesterol (CHO) as oil phase, and aqueous buffer with and without the antitumoral doxorubicin (DOX) have been studied. The effect of the oil phase/surfactant ratio (O/S) and the DOX incorporation on the structural and rheological properties have been studied in several compositions of ME systems. The rheological analyses were performed through the oscillation stress sweep, creep recovery test, and viscosity test. The combination of the DOX incorporation with the high O/S ratio provided a further viscoelastic structure with linear behavior. Independently of the O/S ratio the oil phase diameter increases according to a sigmoid profile, stabilizing up to 340 min. The apparent viscosity decreases a minimum value with the shear rate, but increases with both the O/S ratio and the DOX incorporation in the system. The structural and rheological properties of the studied MEs were directly dependent on the O/S ratio and can be used to improve the application of the system in the pharmaceutical field. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent47-53-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectMicroemulsionen
dc.subjectDoxorubicinen
dc.subjectRheological analysesen
dc.subjectCholesterolen
dc.subjectStorage modulusen
dc.titleStructure and viscoelastic behavior of pharmaceutical biocompatible anionic microemulsions containing the antitumoral drug compound doxorubicinen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)-
dc.contributor.institutionUFSE-
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniversidade Federal do Rio Grande do Norte (UFRN), Ctr Ciencias Saude, Dept Farm, BR-59010180 Natal, RN, Brazil-
dc.description.affiliationUFSE, Dept Quim, Ctr Ciencias Exatas & Tecnol, BR-4950000 Itabaiana, SE, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.doi10.1016/j.colsurfb.2010.01.004-
dc.identifier.wosWOS:000276272100007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofColloids and Surfaces B: Biointerfaces-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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