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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7796
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dc.contributor.authorFerrari, Priscileila C.-
dc.contributor.authorSouza, Fagner M.-
dc.contributor.authorGiorgetti, Leandro-
dc.contributor.authorOliveira, Giselle F.-
dc.contributor.authorChaud, Marco V.-
dc.contributor.authorFerraz, Humberto G.-
dc.contributor.authorEvangelista, Raul Cesar-
dc.date.accessioned2014-05-20T13:24:49Z-
dc.date.accessioned2016-10-25T16:45:28Z-
dc.date.available2014-05-20T13:24:49Z-
dc.date.available2016-10-25T16:45:28Z-
dc.date.issued2012-03-01-
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2011.11.027-
dc.identifier.citationCarbohydrate Polymers. Oxford: Elsevier B.V., v. 87, n. 4, p. 2526-2531, 2012.-
dc.identifier.issn0144-8617-
dc.identifier.urihttp://hdl.handle.net/11449/7796-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7796-
dc.description.abstractThe purpose of this study was to prepare and characterize coated pellets for controlled drug delivery. The influence of chitosan (CS) in pellets was evaluated by swelling, in vitro drug release and intestinal permeation assays. Pellets were coated with an enteric polymer, Kollicoat (R) MAE 30 DP, in a fluidized-bed apparatus and the coating formulations were based on a factorial design. Metronidazole (MT) released from coated and uncoated pellets were assessed by dissolution method using Apparatus I. Intestinal permeation was evaluated by everted intestinal sac model in rats, used to study the absorption of MT from coated pellets containing CS or not through the intestinal tissue. Although the film coating avoided drug dissolution in gastric medium, the overall drug release and intestinal permeation were dependent on the presence of CS. Thus, pellets containing CS show potential as a system for controlled drug delivery. (C) 2011 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent2526-2531-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectPelletsen
dc.subjectChitosanen
dc.subjectEnteric coatingen
dc.subjectMetronidazoleen
dc.subjectControlled drug deliveryen
dc.subjectEverted intestinal sac modelen
dc.titleIn vitro drug permeation from chitosan pelletsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionSorocaba Univ-
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Drugs & Pharmaceut, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Dept Pharm, Sch Pharmaceut Sci, BR-05508000 São Paulo, Brazil-
dc.description.affiliationSorocaba Univ, Pharmaceut Sci Postgrad Program, BR-18023000 Sorocaba, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Drugs & Pharmaceut, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.doi10.1016/j.carbpol.2011.11.027-
dc.identifier.wosWOS:000299969800022-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCarbohydrate Polymers-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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