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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/7800
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dc.contributor.authordos Santos, Jean Leandro-
dc.contributor.authorLanaro, Carolina-
dc.contributor.authorLima, Lidia Moreira-
dc.contributor.authorGambero, Sheley-
dc.contributor.authorFranco-Penteado, Carla Fernanda-
dc.contributor.authorAexandre-Moreira, Magna Suzana-
dc.contributor.authorWade, Marlene-
dc.contributor.authorYerigenahally, Shobha-
dc.contributor.authorKutlar, Abdullah-
dc.contributor.authorMeiler, Steffen E.-
dc.contributor.authorCosta, Fernando Ferreira-
dc.contributor.authorChung, ManChin-
dc.date.accessioned2014-05-20T13:24:49Z-
dc.date.accessioned2016-10-25T16:45:28Z-
dc.date.available2014-05-20T13:24:49Z-
dc.date.available2016-10-25T16:45:28Z-
dc.date.issued2011-08-25-
dc.identifierhttp://dx.doi.org/10.1021/jm200531f-
dc.identifier.citationJournal of Medicinal Chemistry. Washington: Amer Chemical Soc, v. 54, n. 16, p. 5811-5819, 2011.-
dc.identifier.issn0022-2623-
dc.identifier.urihttp://hdl.handle.net/11449/7800-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7800-
dc.description.abstractA novel series of thalidomide derivatives (4a-f) designed by molecular hybridization were synthesized and evaluated in vitro and in vivo for their potential use in the oral treatment of sickle cell disease symptoms. Compounds 4a-f demonstrated analgesic, anti-inflammatory, and NO-donor properties. Compounds 4c and 4d were considered promising candidate drugs and were further evaluated in transgenic sickle cell mice to determine their capacity to reduce the levels of the proinflammatory cytokine tumor necrosis factor alpha (TNF alpha). Unlike hydroxyurea, the compounds reduced the concentrations of TNF alpha to levels similar to those induced with the control dexamethasone (300 mu mol/kg). These compounds are novel lead drug candidates with multiple beneficial actions in the treatment of sickle cell disease symptoms and offer an alternative to hydroxyurea treatment.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent5811-5819-
dc.language.isoeng-
dc.publisherAmer Chemical Soc-
dc.sourceWeb of Science-
dc.titleDesign, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds To Treat Sickle Cell Disease Symptomsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.contributor.institutionUniversidade Federal de Alagoas (UFAL)-
dc.contributor.institutionMed Coll Georgia-
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Med, Lab Pesquisa & Desenvolvimento Farmacos Lapdesf, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv Campinas UNICAMP, Haematol & Haemotherapy Ctr, Hemoctr, BR-13083970 Campinas, SP, Brazil-
dc.description.affiliationUniv Fed Rio de Janeiro, Fac Farm, Lab Avaliacao & Sintese Subst Bioat, BR-21944971 Rio de Janeiro, Brazil-
dc.description.affiliationUniversidade Federal de Alagoas (UFAL), Inst Ciencias Biol & Saude, Lab Farmacol & Imunidale LaFI, Maceio, AL, Brazil-
dc.description.affiliationMed Coll Georgia, Dept Anesthesiol & Perioperat Med, Augusta, GA 30912 USA-
dc.description.affiliationMed Coll Georgia, Sickle Cell Ctr, Augusta, GA 30912 USA-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Med, Lab Pesquisa & Desenvolvimento Farmacos Lapdesf, BR-14801902 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 10/12495-6-
dc.description.sponsorshipIdFAPESP: 07/56115-0-
dc.identifier.doi10.1021/jm200531f-
dc.identifier.wosWOS:000294077300014-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Medicinal Chemistry-
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