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DC Field | Value | Language |
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dc.contributor.author | Santos, Jean Leandro dos | - |
dc.contributor.author | Chin, Chung Man | - |
dc.date.accessioned | 2014-05-20T13:24:50Z | - |
dc.date.accessioned | 2016-10-25T16:45:29Z | - |
dc.date.available | 2014-05-20T13:24:50Z | - |
dc.date.available | 2016-10-25T16:45:29Z | - |
dc.date.issued | 2011-05-01 | - |
dc.identifier | http://dx.doi.org/10.2174/092986711795656117 | - |
dc.identifier.citation | Current Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 18, n. 15, p. 2339-2358, 2011. | - |
dc.identifier.issn | 0929-8673 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7810 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/7810 | - |
dc.description.abstract | Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. SCD is a genetic disease characterized by punctual mutation that basis on the exchange of glutamic acid to valine in a beta chain of hemoglobin. In deoxygenated state, the interaction among the beta chains leads to hemoglobin polymerization carrying out to deformation of cytoskeleton structure of red blood cells to a sickle shape. Currently, the treatment is performed with the antineoplasic drug hydroxyurea. This review summarizes current knowledge about possible targets and the approaches to discover new compounds to treat the SCD symptoms. Drug design based on therapeutical application and molecular modifications strategies will be discussed. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | PADC-UNESP | - |
dc.format.extent | 2339-2358 | - |
dc.language.iso | eng | - |
dc.publisher | Bentham Science Publ Ltd | - |
dc.source | Web of Science | - |
dc.subject | Chelating agents | en |
dc.subject | drug discovery | en |
dc.subject | erythrocyte dehydratation | en |
dc.subject | fetal hemoglobin | en |
dc.subject | hydroxyurea | en |
dc.subject | nitric oxide | en |
dc.subject | sickle cell disease | en |
dc.subject | vasodilatation | en |
dc.subject | hemoglobin modifiers | en |
dc.subject | hemoglobin inducers | en |
dc.subject | gardos channel | en |
dc.subject | sickle cell treatment | en |
dc.subject | vasodilation | en |
dc.subject | phytomedicines | en |
dc.title | Recent Insights on the Medicinal Chemistry of Sickle Cell Disease | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Estadual Paulista UNESP, Lapdesf Lab Pesquisa & Desenvolvimento Farm, Dept Farm & Med, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Lapdesf Lab Pesquisa & Desenvolvimento Farm, Dept Farm & Med, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.sponsorshipId | FAPESP: 10/12495-6 | - |
dc.description.sponsorshipId | PADC-UNESP: 107/10 | - |
dc.identifier.doi | 10.2174/092986711795656117 | - |
dc.identifier.wos | WOS:000290613300012 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Current Medicinal Chemistry | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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