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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7810
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dc.contributor.authorSantos, Jean Leandro dos-
dc.contributor.authorChin, Chung Man-
dc.date.accessioned2014-05-20T13:24:50Z-
dc.date.accessioned2016-10-25T16:45:29Z-
dc.date.available2014-05-20T13:24:50Z-
dc.date.available2016-10-25T16:45:29Z-
dc.date.issued2011-05-01-
dc.identifierhttp://dx.doi.org/10.2174/092986711795656117-
dc.identifier.citationCurrent Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 18, n. 15, p. 2339-2358, 2011.-
dc.identifier.issn0929-8673-
dc.identifier.urihttp://hdl.handle.net/11449/7810-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7810-
dc.description.abstractSickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. SCD is a genetic disease characterized by punctual mutation that basis on the exchange of glutamic acid to valine in a beta chain of hemoglobin. In deoxygenated state, the interaction among the beta chains leads to hemoglobin polymerization carrying out to deformation of cytoskeleton structure of red blood cells to a sickle shape. Currently, the treatment is performed with the antineoplasic drug hydroxyurea. This review summarizes current knowledge about possible targets and the approaches to discover new compounds to treat the SCD symptoms. Drug design based on therapeutical application and molecular modifications strategies will be discussed.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipPADC-UNESP-
dc.format.extent2339-2358-
dc.language.isoeng-
dc.publisherBentham Science Publ Ltd-
dc.sourceWeb of Science-
dc.subjectChelating agentsen
dc.subjectdrug discoveryen
dc.subjecterythrocyte dehydratationen
dc.subjectfetal hemoglobinen
dc.subjecthydroxyureaen
dc.subjectnitric oxideen
dc.subjectsickle cell diseaseen
dc.subjectvasodilatationen
dc.subjecthemoglobin modifiersen
dc.subjecthemoglobin inducersen
dc.subjectgardos channelen
dc.subjectsickle cell treatmenten
dc.subjectvasodilationen
dc.subjectphytomedicinesen
dc.titleRecent Insights on the Medicinal Chemistry of Sickle Cell Diseaseen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista UNESP, Lapdesf Lab Pesquisa & Desenvolvimento Farm, Dept Farm & Med, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Lapdesf Lab Pesquisa & Desenvolvimento Farm, Dept Farm & Med, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 10/12495-6-
dc.description.sponsorshipIdPADC-UNESP: 107/10-
dc.identifier.doi10.2174/092986711795656117-
dc.identifier.wosWOS:000290613300012-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCurrent Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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