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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/7825
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dc.contributor.authorMainardes, Rubiana M.-
dc.contributor.authorGremião, Maria Palmira Daflon-
dc.date.accessioned2014-05-20T13:24:51Z-
dc.date.available2014-05-20T13:24:51Z-
dc.date.issued2009-01-01-
dc.identifierhttp://dx.doi.org/10.4067/S0716-97602009000300010-
dc.identifier.citationBiological Research. Santiago: Soc Biolgia Chile, v. 42, n. 3, p. 357-364, 2009.-
dc.identifier.issn0716-9760-
dc.identifier.urihttp://hdl.handle.net/11449/7825-
dc.description.abstractThe development and validation of a simple and accurate method based on HPLC with ultraviolet detection for the quantification of zidovudine in rat plasma and its application to a pharmacokinetic study following a single intranasal dose zidovudine is described. Zidovudine was extracted from the plasma using, a single-step deproteinization. Chromatographic separation of zidovudine from interfering components wits achieved with a C-18 reverse phase column, a mobile phase Consisting of a mixture of sodium acetate buffer (55 mM) with pH adjusted to 7.0 and acetonitrile (91: 9 v/v) and UV detection set at 265 run. The method was linear from 100 to 10000 ng.mL(-1) (r(2) >= 0.9995), and zidovudine had a mean recovery from plasma of 92.8%. The coefficient of variation of inter-day and intra-day quality control samples was less than 15%. After a single intranasal dose of zidovudine administered to rats, pharmacokinetic parameters (AUC(0-24), C(max), t(max), t(1/2)) were determined. The proposed method was found to be simple, specific. accurate, and precise and could be applied to the quantitative analysis of clinical pharmacokinetic studies of zidovudine in rats.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent357-364-
dc.language.isoeng-
dc.publisherSoc Biolgia Chile-
dc.sourceWeb of Science-
dc.subjectRP-HPLCen
dc.subjectvalidationen
dc.subjectAZTen
dc.subjectpharmacokineticsen
dc.subjectintranasal deliveryen
dc.titleReversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administrationen
dc.typeoutro-
dc.contributor.institutionUniv Estadual Centro Oeste-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Centro Oeste, Dept Farm, BR-85040080 Guarapuava, PR, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 05/50994-6-
dc.identifier.wosWOS:000270893400010-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0716-97602009000300010-en.pdf-
dc.relation.ispartofBiological Research-
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