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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7841
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dc.contributor.authorBonfilio, Rudy-
dc.contributor.authorPires, Sumaia A.-
dc.contributor.authorFerreira, Leonardo M. B.-
dc.contributor.authorde Almeida, Adelia E.-
dc.contributor.authorDoriguetto, Antonio C.-
dc.contributor.authorde Araujo, Magali B.-
dc.contributor.authorSalgado, Hérida Regina Nunes-
dc.date.accessioned2014-05-20T13:24:53Z-
dc.date.accessioned2016-10-25T16:45:32Z-
dc.date.available2014-05-20T13:24:53Z-
dc.date.available2016-10-25T16:45:32Z-
dc.date.issued2012-02-01-
dc.identifierhttp://dx.doi.org/10.1002/jps.22799-
dc.identifier.citationJournal of Pharmaceutical Sciences. Malden: Wiley-blackwell, v. 101, n. 2, p. 794-804, 2012.-
dc.identifier.issn0022-3549-
dc.identifier.urihttp://hdl.handle.net/11449/7841-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7841-
dc.description.abstractGlimepiride, an oral antidiabetic drug, is practically insoluble in water and exists in two polymorphic forms, I and II, of which form II has higher solubility in water. Because the dissolution rate of drugs can depend on the crystal form, there is a need to develop discriminating dissolution methods that are sensitive to changes in polymorphic forms. In this work, a dissolution method for the assessment of 4 mg glimepiride tablets was developed and validated. The optimal dissolution conditions were 1000 mL of phosphate buffer (pH 6.8) containing 0.1% (w/v) of sodium dodecyl sulfate as the dissolution medium and a stirring speed of 50 rpm using a paddle apparatus. The results demonstrated that all the data meet the validation acceptance criteria. Subsequently, tablets containing forms I and II of glimepiride were prepared and subjected to dissolution testing. A significant influence of polymorphism on the dissolution properties of glimepiride tablets was observed. These results suggested that the raw material used to produce glimepiride tablets must be strictly controlled because they may produce undesirable and unpredictable effects. (C) 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:794804, 2012en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)-
dc.format.extent794-804-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectglimepirideen
dc.subjectdissolution rateen
dc.subjectHPLCen
dc.subjectmicroscopyen
dc.subjectpolymorphism of pharmaceuticalsen
dc.subjectX-ray diffractometryen
dc.subjectinfrared spectroscopyen
dc.subjectdifferential scanning calorimetryen
dc.titleA discriminating dissolution method for glimepiride polymorphsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)-
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farm & Medicamentos, BR-14801902 São Paulo, Brazil-
dc.description.affiliationUniv Fed Alfenas, Dept Farm, BR-37130000 Alfenas, MG, Brazil-
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Quim, Dept Quim Anal, BR-14801970 São Paulo, Brazil-
dc.description.affiliationUniv Fed Alfenas, Dept Ciencias Exatas, BR-37130000 Alfenas, MG, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farm & Medicamentos, BR-14801902 São Paulo, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Quim, Dept Quim Anal, BR-14801970 São Paulo, Brazil-
dc.identifier.doi10.1002/jps.22799-
dc.identifier.wosWOS:000298475400031-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Pharmaceutical Sciences-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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