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dc.contributor.authorBahia, D.-
dc.contributor.authorFont, J.-
dc.contributor.authorKhaouja, A.-
dc.contributor.authorCarreras, N.-
dc.contributor.authorEspuny, R.-
dc.contributor.authorCicarelli, RMB-
dc.contributor.authorIngelmo, M.-
dc.contributor.authorBach-Elias, M.-
dc.date.accessioned2014-05-20T13:24:56Z-
dc.date.available2014-05-20T13:24:56Z-
dc.date.issued1999-04-01-
dc.identifierhttp://dx.doi.org/10.1046/j.1432-1327.1999.00287.x-
dc.identifier.citationEuropean Journal of Biochemistry. Oxford: Blackwell Science Ltd, v. 261, n. 2, p. 371-378, 1999.-
dc.identifier.issn0014-2956-
dc.identifier.urihttp://hdl.handle.net/11449/7871-
dc.description.abstractTwo regions common to all UsnRNP core polypeptides have been described: Sm motif 1 and Sm motif 2. Rabbits were immunized with a 22 amino-acid peptide containing one segment of Sm motif 1 (YRGTLVSTDNYFNLQL-NEAEEF, corresponding to residues 11-32) from yeast F protein. After immunization, the rabbit sera contained antibodies that not only reacted specifically with the peptide from yeast F protein but also cross-reacted with Sm polypeptides from mammals; that is, with purified human U1snRNPs. The results suggest that the peptide used and human Sm polypeptides contain a common feature recognized by the polyclonal antibodies. A large collection of human systemic lupus erythematosus sera was assayed using the yeast peptide as an antigen source. Seventy per cent of systemic lupus erythematosus sera contain an antibody specificity that cross-reacts with the yeast peptide.en
dc.format.extent371-378-
dc.language.isoeng-
dc.publisherBlackwell Science-
dc.sourceWeb of Science-
dc.subjectautoimmunitypt
dc.subjectepitope mappingpt
dc.subjectpeptide-ELISApt
dc.subjectSm motif 1pt
dc.subjectUsnRNPspt
dc.titleAntibodies to yeast Sm motif 1 cross-react with human Sm core polypeptidesen
dc.typeoutro-
dc.contributor.institutionCSIC-
dc.contributor.institutionHosp Clin & Prov Barcelona-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationCSIC, IIBB, ES-08034 Barcelona, Spain-
dc.description.affiliationHosp Clin & Prov Barcelona, Syst Autoimmune Dis Unit, Barcelona, Spain-
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Araraquara, SP, Brazil-
dc.identifier.doi10.1046/j.1432-1327.1999.00287.x-
dc.identifier.wosWOS:000080471400004-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000080471400004.pdf-
dc.relation.ispartofEuropean Journal of Biochemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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