Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/7904
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nunes-de-Souza, Vanessa | - |
dc.contributor.author | Nunes-de-Souza, Ricardo | - |
dc.contributor.author | Rodgers, Robert John | - |
dc.contributor.author | Canto-de-Souza, Azair | - |
dc.date.accessioned | 2014-05-20T13:25:00Z | - |
dc.date.accessioned | 2016-10-25T16:45:39Z | - |
dc.date.available | 2014-05-20T13:25:00Z | - |
dc.date.available | 2016-10-25T16:45:39Z | - |
dc.date.issued | 2011-12-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.bbr.2011.07.056 | - |
dc.identifier.citation | Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 225, n. 2, p. 547-553, 2011. | - |
dc.identifier.issn | 0166-4328 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7904 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/7904 | - |
dc.description.abstract | Several lines of evidence support the involvement of serotonergic (5-HT) neurons of the median raphe nucleus (MRN) in anxiety-like behaviour. In this context, it is known that blockade of 5-HT1A somatodendritic autoreceptors in the midbrain raphe nuclei increases the firing rate of these neurons, disinhibiting 5-HT release in postsynaptic target areas such as amygdala, hippocampus and periaqueductal grey matter (PAG). However, while activation of 5-HT1A or 5-HT2 receptors in forebrain targets such as the amygdala or hippocampus enhances anxiety-like behaviours in rodents, stimulation of both receptor subtypes in the midbrain PAG markedly reduces anxiety-like behaviour. In view of these findings, the present study investigated whether the anti-anxiety effects induced by pharmacological disinhibition of 5-HT neurons in the MRN are attenuated by the blockade of 5-HT2 receptors within the PAG. Mice received combined intra-PAG injection with ketanserin (10 nmol/0.1 mu l), a 5-HT2 receptor antagonist, followed by intra-MRN injection of WAY-100635 (5.6 nmol/0.1 mu l), a highly selective 5-HT1A receptor antagonist. They were then individually exposed to the elevated plus-maze (EPM), with the videotaped behavioural sessions subsequently scored for both conventional and ethological measures. The results confirmed that intra-MRN infusion of WAY100635 reduces behavioural indices of anxiety without significantly altering general activity measures, and further showed that this effect was completely blocked by intra-PAG pretreatment with an intrinsically-inactive dose of ketanserin. Together, these results suggest that 5HT(2) receptor populations located within the midbrain PAG play a significant role in the reduction of anxiety observed following disinhibition of 5-HT neurons in the MRN. (C) 2011 Published by Elsevier B.V. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 547-553 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Anxiety | en |
dc.subject | Elevated plus-maze | en |
dc.subject | 5-HT2 receptors | en |
dc.subject | PAG | en |
dc.subject | Median raphe nucleus | en |
dc.subject | Mice | en |
dc.title | Blockade of 5-HT2 receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT1A receptor antagonism in the median raphe nucleus in mice | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade Federal de São Carlos (UFSCar) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Univ Leeds | - |
dc.description.affiliation | UFSCar UNESP, Joint Grad Program Physiol Sci, BR-13565905 São Carlos, SP, Brazil | - |
dc.description.affiliation | CECH UFSCar, Dept Psychol, Psychobiol Grp, BR-13565905 São Carlos, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliation | USP, Inst Neurosci & Behav IneC, BR-14040901 Ribeirao Preto, SP, Brazil | - |
dc.description.affiliation | Univ Leeds, Inst Psychol Sci, Behav Neurosci Lab, Leeds LS2 9JT, W Yorkshire, England | - |
dc.description.affiliationUnesp | UFSCar UNESP, Joint Grad Program Physiol Sci, BR-13565905 São Carlos, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.sponsorshipId | CNPq: 303580/2009-7 | - |
dc.identifier.doi | 10.1016/j.bbr.2011.07.056 | - |
dc.identifier.wos | WOS:000295996800021 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Behavioural Brain Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.