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DC Field | Value | Language |
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dc.contributor.author | Chorilli, Marlus | - |
dc.contributor.author | Bonfilio, Rudy | - |
dc.contributor.author | Chicarelli, Renata da Silva | - |
dc.contributor.author | Salgado, Hérida Regina Nunes | - |
dc.date.accessioned | 2014-05-20T13:25:02Z | - |
dc.date.available | 2014-05-20T13:25:02Z | - |
dc.date.issued | 2011-04-01 | - |
dc.identifier | http://dx.doi.org/10.1039/c0ay00598c | - |
dc.identifier.citation | Analytical Methods. Cambridge: Royal Soc Chemistry, v. 3, n. 4, p. 985-990, 2011. | - |
dc.identifier.issn | 1759-9660 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7918 | - |
dc.description.abstract | Sibutramine is a monoamine re-uptake inhibitor used for the treatment of obesity. In the present study a rapid, sensitive and economical HPLC method was developed and fully validated for analysis of sibutramine HCl in pharmaceutical capsules. HPLC analyses were carried out by using an isocratic elution mode with a mobile phase constituted by sodium phosphate buffer (pH 2.5) and methanol (30 : 70, v/v), flow rate at 1.0 mL min(-1), column temperature at 40 degrees C, UV detection wavelength at 225 nm and 20 mu L of injection volume. The validation parameters were in accordance with FDA and ICH specifications, showing accuracy, precision, selectivity, robustness and linearity from 4.5 to 19.5 mg L(-1) of sibutramine HCl. The limits of detection and quantification were 0.666 and 2.018 mg L(-1), respectively. The validated method is suitable for quality control applications and its advantages over the already existing methods are simplicity and reduced analysis time. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Programa de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC) | - |
dc.format.extent | 985-990 | - |
dc.language.iso | eng | - |
dc.publisher | Royal Soc Chemistry | - |
dc.source | Web of Science | - |
dc.title | Development and validation of an analytical method by RP-HPLC for quantification of sibutramine hydrochloride in pharmaceutical capsules | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Estadual Paulista, Dept Farmacos & Med, Fac Ciencias Farmaceut, UNESP, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Farmacos & Med, Fac Ciencias Farmaceut, UNESP, BR-14801902 Araraquara, SP, Brazil | - |
dc.identifier.doi | 10.1039/c0ay00598c | - |
dc.identifier.wos | WOS:000292164200029 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.identifier.file | WOS000292164200029.pdf | - |
dc.relation.ispartof | Analytical Methods | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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