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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7918
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dc.contributor.authorChorilli, Marlus-
dc.contributor.authorBonfilio, Rudy-
dc.contributor.authorChicarelli, Renata da Silva-
dc.contributor.authorSalgado, Hérida Regina Nunes-
dc.date.accessioned2014-05-20T13:25:02Z-
dc.date.available2014-05-20T13:25:02Z-
dc.date.issued2011-04-01-
dc.identifierhttp://dx.doi.org/10.1039/c0ay00598c-
dc.identifier.citationAnalytical Methods. Cambridge: Royal Soc Chemistry, v. 3, n. 4, p. 985-990, 2011.-
dc.identifier.issn1759-9660-
dc.identifier.urihttp://hdl.handle.net/11449/7918-
dc.description.abstractSibutramine is a monoamine re-uptake inhibitor used for the treatment of obesity. In the present study a rapid, sensitive and economical HPLC method was developed and fully validated for analysis of sibutramine HCl in pharmaceutical capsules. HPLC analyses were carried out by using an isocratic elution mode with a mobile phase constituted by sodium phosphate buffer (pH 2.5) and methanol (30 : 70, v/v), flow rate at 1.0 mL min(-1), column temperature at 40 degrees C, UV detection wavelength at 225 nm and 20 mu L of injection volume. The validation parameters were in accordance with FDA and ICH specifications, showing accuracy, precision, selectivity, robustness and linearity from 4.5 to 19.5 mg L(-1) of sibutramine HCl. The limits of detection and quantification were 0.666 and 2.018 mg L(-1), respectively. The validated method is suitable for quality control applications and its advantages over the already existing methods are simplicity and reduced analysis time.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)-
dc.format.extent985-990-
dc.language.isoeng-
dc.publisherRoyal Soc Chemistry-
dc.sourceWeb of Science-
dc.titleDevelopment and validation of an analytical method by RP-HPLC for quantification of sibutramine hydrochloride in pharmaceutical capsulesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista, Dept Farmacos & Med, Fac Ciencias Farmaceut, UNESP, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Farmacos & Med, Fac Ciencias Farmaceut, UNESP, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.doi10.1039/c0ay00598c-
dc.identifier.wosWOS:000292164200029-
dc.rights.accessRightsAcesso restrito-
dc.identifier.fileWOS000292164200029.pdf-
dc.relation.ispartofAnalytical Methods-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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