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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7954
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dc.contributor.authorLopes, Cristiani Capistrano Gonçalves de Oliveira-
dc.contributor.authorSalgado, Hérida Regina Nunes-
dc.date.accessioned2014-05-20T13:25:08Z-
dc.date.available2014-05-20T13:25:08Z-
dc.date.issued2008-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422008000700039-
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1831-1835, 2008.-
dc.identifier.issn0100-4042-
dc.identifier.urihttp://hdl.handle.net/11449/7954-
dc.description.abstractThe microbiological bioassay, UV-spectrophotometry and HPLC methods for assaying gatifloxacin in tablets were compared. Validation parameters such as linearity, precision, accuracy, limit of detection and limit of quantitation were determined. Beer's law was obeyed in the ranges 4.0-14.0 μg/mL for HPLC and UV-spectrophotometric method, and 4.0-16.0 μg/mL for bioassay. All methods were reliable within acceptable limits for antibiotic pharmaceutical preparations being accurate, precise and reproducible. The bioassay and HPLC are more specific than UV-spectrophotometric analysis. The application of each method as a routine analysis should be investigated considering cost, simplicity, equipment, solvents, speed, and application to large or small workloads.en
dc.description.sponsorshipPACD-FCFAr-UNESP-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent1831-1835-
dc.language.isoeng-
dc.publisherSociedade Brasileira de Química-
dc.sourceSciELO-
dc.subjectfluoroquinoloneen
dc.subjectgatifloxacinen
dc.subjectpharmaceutical analysisen
dc.titlePerformance characteristics of bioassay UV-spectrophotometry and high perfomance liquid chromatographic determination of gatifloxacin in tabletsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos-
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos-
dc.identifier.doi10.1590/S0100-40422008000700039-
dc.identifier.scieloS0100-40422008000700039-
dc.identifier.wosWOS:000262432800039-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0100-40422008000700039.pdf-
dc.relation.ispartofQuímica Nova-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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