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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7956
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dc.contributor.authorMendonça, Taciane Ferreira-
dc.contributor.authorBarros, Eliézer Giannini de-
dc.contributor.authorPereira, Gislaine Ribeiro-
dc.contributor.authorAraújo, Magali Benjamim de-
dc.contributor.authorBonfilio, Rudy-
dc.date.accessioned2014-05-20T13:25:09Z-
dc.date.available2014-05-20T13:25:09Z-
dc.date.issued2011-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422011000300027-
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 34, n. 3, p. 520-526, 2011.-
dc.identifier.issn0100-4042-
dc.identifier.urihttp://hdl.handle.net/11449/7956-
dc.description.abstractThis work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution medium and paddle as the apparatus at 50 rpm. The drug concentrations in the dissolution media were determined by UV spectrophotometry and HPLC and a statistical analysis revealed that there were significant differences between HPLC and spectrophotometry. This study illustrates the importance of an official method for the dissolution test, since there is no official monograph for diltiazem hydrochloride in capsules.en
dc.description.sponsorshipCenter of Pharmaceutical Equivalence - Nucleus Quality Control-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent520-526-
dc.language.isoeng-
dc.publisherSociedade Brasileira de Química-
dc.sourceSciELO-
dc.subjectdissolutionen
dc.subjecthigh performance liquid chromatographyen
dc.subjectspectrophotometryen
dc.titleDevelopment and validation of a dissolution test for diltiazem hydrochloride in immediate release capsulesen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Federal de Alfenas Centro de Equivalência Farmacêutica do Núcleo Controle de Qualidade Departamento de Farmácia-
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos-
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos-
dc.identifier.doi10.1590/S0100-40422011000300027-
dc.identifier.scieloS0100-40422011000300027-
dc.identifier.wosWOS:000289857500027-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0100-40422011000300027.pdf-
dc.relation.ispartofQuímica Nova-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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