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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/8029
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dc.contributor.authorPavan, Fernando Rogério-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.contributor.authorCoelho, Roberta Gomes-
dc.contributor.authorCoutinho, Isabel Duarte-
dc.contributor.authorHonda, Neli Kika-
dc.contributor.authorCardoso, Claudia Andréa Lima-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorLeite, Sergio Roberto de Andrade-
dc.contributor.authorSato, Daisy Nakamura-
dc.date.accessioned2014-05-20T13:25:22Z-
dc.date.available2014-05-20T13:25:22Z-
dc.date.issued2009-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422009000500026-
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 32, n. 5, p. 1222-1226, 2009.-
dc.identifier.issn0100-4042-
dc.identifier.urihttp://hdl.handle.net/11449/8029-
dc.description.abstractThe anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent1222-1226-
dc.language.isoeng-
dc.publisherSociedade Brasileira de Química-
dc.sourceSciELO-
dc.subjectCampomanesia adamantiumen
dc.subjectanti-Mycobacterium tuberculosisen
dc.subjectflavonoidsen
dc.titleEvaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)en
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Ciências Biológicas-
dc.description.affiliationUniversidade Federal de Mato Grosso do Sul Departamento de Química-
dc.description.affiliationUniversidade Federal de Mato Grosso do Sul Curso de Química-
dc.description.affiliationUniversidade Estadual Paulista Instituto de Química Departamento de Química-
dc.description.affiliationInstituto Adolfo Lutz de Ribeirão Preto-
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Ciências Biológicas-
dc.description.affiliationUnespUniversidade Estadual Paulista Instituto de Química Departamento de Química-
dc.identifier.doi10.1590/S0100-40422009000500026-
dc.identifier.scieloS0100-40422009000500026-
dc.identifier.wosWOS:000269124800026-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0100-40422009000500026.pdf-
dc.relation.ispartofQuímica Nova-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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