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http://acervodigital.unesp.br/handle/11449/8118
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DC Field | Value | Language |
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dc.contributor.author | Peccinini, Rosangela Goncalves | - |
dc.contributor.author | Ximenes, Valdecir Farias | - |
dc.contributor.author | Cesarino, Evandro J. | - |
dc.contributor.author | Lanchote, Vera L. | - |
dc.date.accessioned | 2014-05-20T13:25:34Z | - |
dc.date.accessioned | 2016-10-25T16:46:00Z | - |
dc.date.available | 2014-05-20T13:25:34Z | - |
dc.date.available | 2016-10-25T16:46:00Z | - |
dc.date.issued | 2008-07-01 | - |
dc.identifier | http://dx.doi.org/10.1002/bdd.613 | - |
dc.identifier.citation | Biopharmaceutics & Drug Disposition. Chichester: John Wiley & Sons Ltd, v. 29, n. 5, p. 280-288, 2008. | - |
dc.identifier.issn | 0142-2782 | - |
dc.identifier.uri | http://hdl.handle.net/11449/8118 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/8118 | - |
dc.description.abstract | An enantioselective high-performance liquid chromatographic method for the analysis of carvedilol in plasma and urine was developed and validated using (-)-menthyl chloroformate (MCF) as a derivatizing reagent. Chloroform was used for extraction, and analysis was performed by HPLC on a C18 column with a fluorescence detector. The quantitation limit was 0.25 ng/ml for S(-)-carvedilol in plasma and 0.5 ng/ml for R(+)-carvedilol in plasma and for both enantiomers in urine. The method was applied to the study of enantioselectivity in the pharmacokinetics of carvedilol administered in a multiple dose regimen (25mg/12h) to a hypertensive elderly female patient. The data obtained demonstrated highest plasma levels for the R(+)-carvedilol(AUCSS 75.64 vs 37.29ng/ml). The enantiomeric ratio R(+)/S(-) was 2.03 for plasma and 1.49 0 - 12 for urine (Aeo-12 17.4 vs 11.7 pg). Copyright (c) 2008 John Wiley & Sons, Ltd. | en |
dc.format.extent | 280-288 | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons Ltd | - |
dc.source | Web of Science | - |
dc.subject | carvedilol | en |
dc.subject | enantiomers | en |
dc.subject | HPLC | en |
dc.subject | pharmacokinetics | en |
dc.title | Stereoselective analysis of carvedilol in human plasma and urine using HPLC after chiral derivatization | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ São Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, Brazil | - |
dc.description.affiliation | São Paulo State Univ Julio Mesquita Filho, Fac Sci, São Paulo, Brazil | - |
dc.description.affiliation | São Paulo State Univ Julio Mesquita Filho, Sch Pharmaceut Sci, São Paulo, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ Julio Mesquita Filho, Fac Sci, São Paulo, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ Julio Mesquita Filho, Sch Pharmaceut Sci, São Paulo, Brazil | - |
dc.identifier.doi | 10.1002/bdd.613 | - |
dc.identifier.wos | WOS:000258081300004 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Biopharmaceutics & Drug Disposition | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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