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dc.contributor.authorAmaral, Sandra Lia do-
dc.contributor.authorMichelini, L. C.-
dc.date.accessioned2014-05-20T13:26:06Z-
dc.date.available2014-05-20T13:26:06Z-
dc.date.issued2011-09-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2011007500055-
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 44, n. 9, p. 814-826, 2011.-
dc.identifier.issn0100-879X-
dc.identifier.urihttp://hdl.handle.net/11449/8359-
dc.description.abstractThere is accumulating evidence that physical inactivity, associated with the modern sedentary lifestyle, is a major determinant of hypertension. It represents the most important modifiable risk factor for cardiovascular diseases, which are the leading cause of morbidity and mortality for both men and women. In addition to involving sympathetic overactivity that alters hemodynamic parameters, hypertension is accompanied by several abnormalities in the skeletal muscle circulation including vessel rarefaction and increased arteriole wall-to-lumen ratio, which contribute to increased total peripheral resistance. Low-intensity aerobic training is a promising tool for the prevention, treatment and control of high blood pressure, but its efficacy may differ between men and women and between male and female animals. This review focuses on peripheral training-induced adaptations that contribute to a blood pressure-lowering effect, with special attention to differential responses in male and female spontaneously hypertensive rats (SHR). Heart, diaphragm and skeletal muscle arterioles (but not kidney arterioles) undergo eutrophic outward remodeling in trained male SHR, which contributed to a reduction of peripheral resistance and to a pressure fall. In contrast, trained female SHR showed no change in arteriole wall-to-lumen ratio and no pressure fall. on the other hand, training-induced adaptive changes in capillaries and venules (increased density) were similar in male and female SHR, supporting a similar hyperemic response to exercise.en
dc.format.extent814-826-
dc.language.isoeng-
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)-
dc.sourceWeb of Science-
dc.subjectExercise trainingen
dc.subjectHypertensionen
dc.subjectMicrocirculationen
dc.subjectArteriolesen
dc.subjectCapillariesen
dc.subjectVenulesen
dc.titleEffect of gender on training-induced vascular remodeling in SHRen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508000 São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Dept Educ Fis, Fac Ciencias, Bauru, SP, Brazil-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Ciencias Fisiol, Programa Interinst Posgrad UNESP UFSCAR, BR-13560 São Carlos, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Educ Fis, Fac Ciencias, Bauru, SP, Brazil-
dc.description.affiliationUnespUniversidade Federal de São Carlos (UFSCar), Dept Ciencias Fisiol, Programa Interinst Posgrad UNESP UFSCAR, BR-13560 São Carlos, SP, Brazil-
dc.identifier.scieloS0100-879X2011000900001-
dc.identifier.wosWOS:000295721500001-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0100-879X2011000900001-en.pdf-
dc.relation.ispartofBrazilian Journal of Medical and Biological Research-
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